Smart Design of Nanomaterials for Mitochondria-Targeted Nanotherapeutics.

Angewandte Chemie
Si Si LiewShao Q Yao

Abstract

Mitochondria are the powerhouse of cells. They are vital organelles that maintain cellular function and metabolism. Dysfunction of mitochondria results in various diseases with a great diversity of clinical appearances. In the past, strategies have been developed for fabricating subcellular-targeting drug-delivery nanocarriers, enabling cellular internalization and subsequent organelle localization. Of late, innovative strategies have emerged for the smart design of multifunctional nanocarriers. Hierarchical targeting enables nanocarriers to evade and overcome various barriers encountered upon in vivo administration to reach the organelle with good bioavailability. Stimuli-responsive nanocarriers allow controlled release of therapeutics to occur at the desired target site. Synergistic therapy can be achieved using a combination of approaches such as chemotherapy, gene and phototherapy. In this Review, we survey the field for recent developments and strategies used in the smart design of nanocarriers for mitochondria-targeted therapeutics. Existing challenges and unexplored therapeutic opportunities are also highlighted and discussed to inspire the next generation of mitochondrial-targeting nanotherapeutics.

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Citations

Sep 16, 2020·Chemical Communications : Chem Comm·Yuanyuan ChenBo Tang
Mar 2, 2021·Chemical Communications : Chem Comm·Si Si LiewShao Q Yao
May 15, 2021·Advanced Materials·Sheng WangXiaoyuan Chen
May 21, 2021·Frontiers in Chemistry·Haiwei WangWei Huang
May 25, 2021·Chemical Society Reviews·Yuxuan XiongXiangliang Yang
Jun 11, 2021·RNA Biology·Huixin LiangQiyi Zhao
Jun 19, 2021·Nano Letters·Mingming LiZhilin Yu
Aug 13, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guo LiLi Wu
Aug 27, 2021·Chemistry : a European Journal·Qicai XiaoLiqian Gao
Oct 28, 2021·Chemical Communications : Chem Comm·Sumit Kumar Pramanik, Amitva Das

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