Smart diagnostic nano-agents for cerebral ischemia.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Christos TapeinosGianni Ciofani

Abstract

Cerebral ischemia (or ischemic stroke) is undeniably one of the most important life-threatening cerebral disorders. It occurs due to a clot formation in one of the blood arteries supplying the brain, causing a reduction or interruption of the blood flow. To date, the use of thrombolytics like the recombinant tissue plasminogen activator or the use of mechanical thrombectomy are the only two food and drug administration-approved treatments. However, these cannot be applied without first evaluating the beneficial or adverse effects on the patient. Thus, imaging is decisive for identifying the appropriateness of each stroke patient, leading potentially to improved therapeutic outcomes. In this review, we will present a variety of diagnostic nano-agents, and a few theranostic ones, for the assessment of ischemic stroke, highlighting their strengths and weaknesses.

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Citations

Jul 8, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yanhui ZhangZongwu Deng

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Methods Mentioned

BETA
imaging techniques
imaging
X-ray
imaging technique
fluorescence imaging
chemical exchange saturation transfer
confocal microscopy

Clinical Trials Mentioned

NCT03463551
NCT01995799
NCT01674257
NCT00659776
NCT02319278

Software Mentioned

IVM
XLCT

Related Concepts

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Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

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