Smart gated magnetic silica mesoporous particles for targeted colon drug delivery: New approaches for inflammatory bowel diseases treatment

Journal of Controlled Release : Official Journal of the Controlled Release Society
Adrián H TeruelFélix Sancenón

Abstract

Magnetic mesoporous silica microparticles were loaded with safranin O (S1) and with hydrocortisone (S2) and the outer surface functionalized with a bulky azo derivative bearing urea moieties. Aqueous suspensions of both solids at pH 7.4 showed negligible payload release whereas a marked delivery was observed in the presence of sodium dithionite due to the rupture of the azo bonds. Besides, a moderate cargo release was observed at acidic pH due to the hydrolysis of the urea bonds that linked the azo derivative onto the external surface of the inorganic scaffolds. In vitro digestion models showed that S1 and S2 microparticles could be used for the controlled release of payload in the reducing colon environment (in which azoreductase enzymes are present). On the other hand, in vivo pharmacokinetic studies in rats showed that safranine O release from S1 microparticles was concentrated in colon. The performance of S2 microparticles for the treatment of colitis in rats (induced by oral administration of a 2,4,6-trinitrobenzenesulfonic acid solution) was tested. The controlled release of hydrocortisone from S2 in the colon of injured rats induced marked reduction in colon/body weight ratio and in clinical activity score. Also, histolo...Continue Reading

Citations

Apr 30, 2019·Small·Andrea BernardosRamón Martínez-Máñez
Apr 24, 2019·Chemistry : a European Journal·Andy Hernández MontotoFélix Sancenón
Mar 13, 2020·Frontiers in Pharmacology·Pramila ChaubeySujata Sawarkar
Sep 10, 2020·International Journal of Molecular Sciences·Adrian H TeruelRamon Martinez-Mañez
Jan 17, 2021·Pharmaceutics·Isabel González-AlvarezRamón Martínez-Máñez
Jun 13, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·N A Bhaskaran, L Kumar
Jul 16, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alba García-FernándezRamón Martínez-Máñez

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