"Smart" Nanoprobes for Visualization of Tumor Microenvironments

Advanced Healthcare Materials
Tiancong MaMingyuan Gao

Abstract

Physiological parameters in tumor microenvironments, including hypoxia, low extracellular pH, enzymes, reducing conditions, and so on, are closely associated with the proliferation, angiogenesis, invasion, and metastasis of cancer, and impact the therapeutic administrations. Therefore, monitoring the tumor microenvironment is significant for diagnosing tumors, predicting the invasion potential, evaluating therapeutic efficacy, planning the treatment, and cancer prognostics. Noninvasive molecular imaging technologies combined with novel "smart" nanoparticle-based activatable probes provide a feasible approach to visualize tumor-associated microenvironment factors. This review summarizes recent achievements in the designs of "smart" molecular imaging nanoprobes responding to the tumor microenvironment-related features, and highlights the state of the art in tumor heterogeneity imaging.

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Citations

Jun 17, 2020·Journal of Biophotonics·Eran A BarnoyDror Fixler
Jul 22, 2020·Advanced Healthcare Materials·Xianfu MengWenbo Bu
Jan 17, 2020·In Vitro Cellular & Developmental Biology. Animal·Yubin PanYan Zhang
Mar 5, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Miaomiao ChenFengling Song
Apr 30, 2021·Frontiers in Chemistry·Yan YangYi Hou
Apr 30, 2021·Frontiers in Chemistry·Yi HouJing Hao

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