Smart Nanotheranostics Responsive to Pathological Stimuli

Frontiers in Bioengineering and Biotechnology
Alessandro ParodiAndrey A Zamyatnin

Abstract

The development of nanotheranostics represents one of the most dynamic technological frontiers in the treatment of different pathological conditions. With the goal in mind to generate nanocarriers with both therapeutic and diagnostic properties, current research aims at implementing these technologies with multiple functions, including targeting, multimodal imaging, and synergistic therapies. The working mechanism of some nanotheranostics relies on physical, chemical, and biological triggers allowing for the activation of the therapeutic and/or the diagnostic properties only at the diseased site. In this review, we explored new advances in the development of smart nanotheranostics responsive to pathological stimuli, including altered pH, oxidative stress, enzymatic expression, and reactive biological molecules with a deep focus on the material used in the field to generate the particles in the context of the analyzed disease.

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Citations

Nov 24, 2020·Advanced Healthcare Materials·Morgan E LorkowskiEfstathios Karathanasis
Jan 7, 2021·Expert Opinion on Drug Delivery·Andrea PerrelliSaverio Francesco Retta
Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·E K Pramod KumarJae Hyung Park
Apr 4, 2021·Pharmaceutics·Rajasekharreddy PalaSurya M Nauli
Aug 10, 2021·Advanced Drug Delivery Reviews·Melgious Jin Yan AngXiaogang Liu

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Methods Mentioned

BETA
fluorescence imaging
irradiating
Fluorescence

Software Mentioned

MCDION
Se

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