Smart triblock dendritic unimolecular micelles as pioneering nanomaterials: Advancement pertaining to architecture and biomedical applications

Journal of Controlled Release : Official Journal of the Controlled Release Society
Prajakta TambeVirendra Gajbhiye

Abstract

Recent interest in triblock dendritic unimolecular micelles has opened a new spectrum for its ubiquitous application in biomedical sciences specially drug delivery. Unimolecular dendritic micelles have brought significant attention due to their high encapsulation efficiency, high-functionality, and site specific confinement capabilities. During the last decade, the number of publications in this field has increased drastically, reinforced by the fact that several clinical trials are underway using micelles for drug delivery. This review unveils the most recent advancement on the synthesis and applications of cutting-edge unimolecular micelles using dendritic and star-shaped molecules emphasizing on triblock copolymers. The major biomedical applications covered in this manuscript are drug/gene/bio-macromolecules delivery to the site of interest, as contrast agents in bio-imaging, and cancer targeted theranostics using stimuli-responsive mechanism.

Citations

Oct 3, 2019·Biomaterials Science·Zhengkui ZhangXiqun Jiang
Aug 21, 2019·Anti-cancer Agents in Medicinal Chemistry·Paromita KunduSanjeeb K Sahoo
Feb 9, 2021·International Journal of Pharmaceutics·Diana CostaAna Figueiras
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Rajesh SalveWassana Yantasee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.