Smartphone Cognitive Behavioral Therapy as an Adjunct to Pharmacotherapy for Refractory Depression: Randomized Controlled Trial

Journal of Medical Internet Research
Akio MantaniNao Kawanishi

Abstract

In the treatment of major depression, antidepressants are effective but not curative. Cognitive behavioral therapy (CBT) is also effective, alone or in combination with pharmacotherapy, but accessibility is a problem. The aim is to evaluate the effectiveness of a smartphone CBT app as adjunctive therapy among patients with antidepressant-resistant major depression. A multisite, assessor-masked, parallel-group randomized controlled trial was conducted in 20 psychiatric clinics and hospitals in Japan. Participants were eligible if they had a primary diagnosis of major depression and were antidepressant-refractory after taking one or more antidepressants at an adequate dosage for four or more weeks. After a 1-week run-in in which participants started the medication switch and had access to the welcome session of the app, patients were randomized to medication switch alone or to medication switch plus smartphone CBT app via the centralized Web system. The smartphone app, called Kokoro-app ("kokoro" means "mind" in Japanese), included sessions on self-monitoring, behavioral activation, and cognitive restructuring presented by cartoon characters. The primary outcome was depression severity as assessed by masked telephone assessors wi...Continue Reading

References

Sep 15, 2001·Journal of General Internal Medicine·K KroenkeJ B Williams
Mar 17, 2004·Controlled Clinical Trials·Heejung BangClarence E Davis
Jun 3, 2004·JAMA : the Journal of the American Medical Association·Koen DemyttenaereUNKNOWN WHO World Mental Health Survey Consortium
Aug 26, 2004·JAMA : the Journal of the American Medical Association·Gregory E SimonMichael Von Korff
Jan 5, 2006·The American Journal of Psychiatry·Madhukar H TrivediUNKNOWN STAR*D Study Team
Mar 24, 2006·The New England Journal of Medicine·A John RushUNKNOWN STAR*D Study Team
Nov 30, 2006·PLoS Medicine·Colin D Mathers, Dejan Loncar
Jan 18, 2008·The New England Journal of Medicine·Erick H TurnerRobert Rosenthal
Oct 13, 2009·The Journal of Clinical Psychiatry·Pim CuijpersGerhard Andersson
Oct 28, 2009·Administration and Policy in Mental Health·Kimberly A HepnerM Audrey Burnam
May 22, 2010·Journal of Psychosomatic Research·Toshi A Furukawa
Aug 6, 2010·The American Journal of Psychiatry·Mark Olfson, Steven C Marcus
Dec 8, 2010·Archives of General Psychiatry·Steven C Marcus, Mark Olfson
Jul 8, 2011·Nature·Pamela Y CollinsDan J Stein
Jul 28, 2011·BMC Medicine·Evelyn BrometRonald C Kessler
Jun 27, 2012·Journal of Medical Internet Research·Sylvia Deidre KauerGeorge Patton
Feb 9, 2013·BMC Psychiatry·Sarah WattsGavin Andrews
Jul 8, 2015·Trials·Norio WatanabeUNKNOWN Steering Committee of the Fun to Learn to Act and Think through Technology Project
Oct 28, 2016·European Child & Adolescent Psychiatry·Koki TakagakiShigeto Yamawaki
Apr 15, 2016·Nature·Emily Anthes
Nov 9, 2016·Contemporary Clinical Trials Communications·Heejung Bang
Nov 16, 2016·Psychiatric Services : a Journal of the American Psychiatric Association·Nigel E BushSteven K Dobscha
Dec 22, 2016·Journal of Medical Internet Research·Patricia A AreanJoaquin A Anguera
Jan 21, 2017·The British Journal of Psychiatry : the Journal of Mental Science·Toshi A FurukawaPim Cuijpers
Aug 26, 2017·Journal of Medical Internet Research·Amy Leigh Rathbone, Julie Prescott

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Citations

Jul 10, 2018·Current Opinion in Psychiatry·Seema Mehrotra, Ravikesh Tripathi
Apr 3, 2020·JMIR MHealth and UHealth·Ignacio MirallesSven Casteleyn
Apr 30, 2020·JMIR MHealth and UHealth·Tania LecomteYasser Khazaal
May 16, 2020·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Donald M HiltyPeter M Yellowlees
Aug 30, 2018·Current Psychiatry Reports·Steven ChanPeter M Yellowlees
Feb 7, 2020·Current Psychiatry Reports·Alejandro Porras-SegoviaEnrique Baca-García
Oct 31, 2019·Journal of Medical Internet Research·Morten Lindbjerg TønningMaria Faurholt-Jepsen
Nov 17, 2020·Experimental Gerontology·Stephen D AntonMarco Pahor
Jan 8, 2022·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Edward HurtteC Prakash Gyawali

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Methods Mentioned

BETA
pharmacotherapy
Cognitive Behavioral Therapy

Software Mentioned

- Web
app
Kokoro

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