Smartphone Nanocolorimetry for On-Demand Lead Detection and Quantitation in Drinking Water

Analytical Chemistry
Hoang NguyenWei-Chuan Shih

Abstract

Lead ions (Pb2+) contamination in drinking water, a major source of lead poisoning to the general population, is typically detected by bulky and costly laboratory analytical instrument. A mobile analytical device for rapid Pb2+ sensing is a growing demand. Herein, we report smartphone nanocolorimetry (SNC) as a new technique to detect and quantify dissolved Pb2+ in drinking water. Specifically, we have employed a single-step sedimentation approach by mixing a controlled quantity of chromate ion (CrO42-) to react with Pb2+ containing solutions to form highly insoluble lead chromate (PbCrO4) nanoparticles as vivid yellow precipitates. This is followed by microscopic color detection and intensity quantitation at nanoscale level using dark-field smartphone microscopy. The sum of the intensity of yellow pixels bears a highly reproducible relationship with Pb2+ concentration between 1.37 and 175 ppb in deionized water and 5-175 ppb in city tap water. In contrast to traditional colorimetric techniques analyzing bulk color changes, SNC achieves unparalleled sensitivity by combining nanocolorimetry with dark-field microscopy and mobilized the metal ions detection by integrating the detection into the smartphone microscope platform. SNC ...Continue Reading

References

Jan 30, 2004·Annual Review of Medicine·Herbert Needleman
May 21, 2008·Analytical Chemistry·Diane Beauchemin
Sep 22, 2012·Lab on a Chip·Li ShenIan Papautsky
Dec 21, 2012·Lab on a Chip·Ahmet F CoskunAydogan Ozcan
Oct 3, 2013·PloS One·Alon GreenbaumAydogan Ozcan
Feb 18, 2014·Regulatory Toxicology and Pharmacology : RTP·Beatrice BoccaGiovanni Forte
Mar 13, 2014·Analytical and Bioanalytical Chemistry·Hu WangGuo-xia Zheng
Oct 16, 2015·Trends in Biotechnology·Sandeep Kumar VashistJohn H T Luong
Dec 1, 2017·Biomedical Optics Express·Yulung SungWei-Chuan Shih
Jan 10, 2018·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Kelly Johnson-ArborRyszard Gajek

❮ Previous
Next ❯

Citations

Jan 16, 2019·Applied Optics·Yu-Lung SungWei-Chuan Shih
Feb 24, 2021·Analytical Chemistry·Peng Fei GaoCheng Zhi Huang
Jul 3, 2021·International Journal of Molecular Sciences·Marziyeh NazariMatthew R Hill
Oct 24, 2019··Wei-Chuan Shih, Wei-Chuan Shih

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.