SMC1A is associated with radioresistance in prostate cancer and acts by regulating epithelial-mesenchymal transition and cancer stem-like properties.

Molecular Carcinogenesis
Sushma YadavDavid A Horne

Abstract

Prostate cancer is one of the most commonly diagnosed cancers and a pressing health challenge in men worldwide. Radiation therapy (RT) is widely considered a standard therapy for advanced as well as localized prostate cancer. Although this primary therapy is associated with high cancer control rates, up to one-third of patients undergoing radiation therapy becomes radio-resistant and/or has tumor-relapse/recurrence. Therefore, focus on new molecular targets and pathways is essential to develop novel radio-sensitizing agents for the effective and safe treatment of prostate cancer. Here, we describe functional studies that were performed to investigate the role of structural maintenance of chromosome-1 (SMC1A) in radioresistance of metastatic prostate cancer cells. Short hairpin RNA (shRNA) was used to suppress SMC1A in metastatic castration-resistant prostate cancer cells, DU145 and PC3. Clonogenic survival assays, Western blot, RT-PCR, and γ-H2AX staining were used to assess the effect of SMC1A knockdown on radiation sensitivity of these prostate cancer cells. We demonstrate that SMC1A is overexpressed in human prostate tumors compared to the normal adjacent tissue. SMC1A knockdown limits the clonogenic potential, epithelial-me...Continue Reading

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Citations

Feb 6, 2019·Journal of Experimental & Clinical Cancer Research : CR·Rihan El BezawyNadia Zaffaroni
Nov 12, 2020·Nature Reviews. Clinical Oncology·Asfar S AzmiRamzi M Mohammad
Sep 8, 2019·Cancer Letters·Tsing TsaoYong Li
Mar 4, 2021·Reproductive Biology and Endocrinology : RB&E·Yingxian JiaJianhong Zhou
May 30, 2021·Medical Oncology·Jacqueline R LimAnn H Kwan
Aug 21, 2021·Frontiers in Oncology·Sílvia SoaresRúben Fernandes

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