smellblind: a gene required for Drosophila olfaction.

Genetics
M Lilly, J Carlson

Abstract

In this article we define and characterize the smellblind gene (sbl). We show that two mutants, sbl and olfDx9, both isolated by virtue of their olfactory phenotypes and analyzed extensively by others with respect to courtship behavior, contain mutations at a single locus. Meiotic recombination, duplication, and deficiency mapping are used to localize this gene, sbl, to cytogenetic position 14F6-15A2-3 on the X chromosome. Mutations of the locus are shown to produce severe defects not only in larval olfactory response to several volatile chemicals, but also in larval contact chemosensory response. Both sbl and olfDx9 give a robust response, however, in a new test of larval phototactic response, which we describe here. Both alleles are shown to be heat-sensitive lethals. Four additional recessive lethal alleles, two EMS-induced, one dysgenic, and one spontaneous, are also described.

Citations

Sep 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mark RosenzweigPaul A Garrity
Mar 7, 2020·Current Biology : CB·Prabhjit Singh, Jeffrey M Donlea
Sep 1, 1991·Brain Research Bulletin·E TabuchiM Kawasaki
Oct 15, 2003·Behavioural Processes·Jean Marc Devaud
Jun 1, 2005·Journal of Neuroscience Methods·Virginia A Min, Barry G Condron
Jan 6, 2007·Pflügers Archiv : European journal of physiology·Dean P Smith
Feb 1, 1994·Evolution; International Journal of Organic Evolution·David Scott
Feb 24, 2007·Behavior Genetics·Nadia ScantleburyAna Regina Campos
Aug 9, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A VitebskyK E Whitlock
Jun 28, 2018·Biology Open·Leif R NeitzelEthan Lee
Apr 17, 2007·The Journal of Comparative Neurology·Julien ColombReinhard F Stocker
Aug 1, 1996·Current Opinion in Neurobiology·D P Smith
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·K F Störtkuhl, R Kettler
Jan 1, 1996·Behavior Genetics·B Gordesky-GoldL Tompkins
Oct 31, 2002·Development·Raphaelle DubruilleBénédicte Durand
Nov 1, 1994·Trends in Neurosciences·A Ferrús, I Canal
May 1, 1996·Trends in Genetics : TIG·J R Carlson
Feb 4, 1999·Annals of the New York Academy of Sciences·A E DubinG L Harris
Dec 1, 1991·Trends in Neurosciences·J Carlson
Apr 1, 1993·Journal of Neurogenetics·W S Neckameyer, K White
Apr 23, 1999·Invertebrate Neuroscience : in·W S Neckameyer, R L Cooper
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D B Pho
Aug 6, 2000·Journal of Neurogenetics·J M WarrickL Tompkins
Oct 1, 1998·Behavioural Brain Research·G O Pflugfelder
Oct 16, 2009·PLoS Neglected Tropical Diseases·Gustavo Ponce GarcíaWilliam C Black IV
May 26, 2010·PloS One·Nadia ScantleburyAna Regina Campos
May 30, 2003·Learning & Memory·Sabine SchererBertram Gerber
Mar 25, 2011·Genetics Research·Robert R H Anholt

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