SMK-1, an essential regulator of DAF-16-mediated longevity

Cell
Suzanne WolffAndrew Dillin

Abstract

Insulin/IGF-1 signaling (IIS) regulates aging in worms, flies, and mice through a well-characterized, highly conserved core set of components. IIS also regulates early developmental decisions, the reproductive status of the animal, innate immunity, and stress-resistance functions. In C. elegans, the sole insulin/IGF-1 receptor, DAF-2, negatively regulates the FOXO transcription factor, DAF-16. We report here on a new component of the IIS longevity pathway, SMK-1, which specifically influences DAF-16-dependent regulation of the aging process in C. elegans by regulating the transcriptional specificity of DAF-16 activity. Localization analysis of DAF-16 places SMK-1 downstream of DAF-16's phosphorylation-dependent relocation to the nucleus. Physiological and transcription analyses indicate that smk-1 is required for the innate immune, UV, and oxidative stress but not the thermal stress functions of DAF-16. SMK-1 therefore plays a role in longevity by modulating DAF-16 transcriptional specificity without affecting other processes regulated by IIS.

References

May 1, 1974·Genetics·S Brenner
Dec 2, 1993·Nature·C KenyonR Tabtiang
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·P L Larsen
Oct 6, 1997·Endocrinology and Metabolism Clinics of North America·M C Riddle
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·B Lakowski, S Hekimi
Mar 13, 2001·The Journal of Biological Chemistry·H MiyaderaK Kita
Aug 15, 2002·Current Biology : CB·Gustavo V MalloJonathan J Ewbank
Oct 26, 2002·Science·Andrew DillinCynthia Kenyon
Apr 12, 2003·Science·Siu Sylvia LeeGary Ruvkun
May 20, 2003·Nature·Pere PuigserverBruce M Spiegelman
Jun 21, 2003·Science·Danielle A GarsinFrederick M Ausubel
Feb 26, 2004·Cell·Maria Carla MottaLeonard Guarente
Jun 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hiroaki DaitokuAkiyoshi Fukamizu
May 26, 2005·FEBS Letters·Patricia T W CohenCristina Vázquez-Martin
Aug 9, 2005·Molecular & Cellular Proteomics : MCP·Anne-Claude GingrasRuedi Aebersold
Aug 19, 2005·Molecular and Cellular Biology·Michelle C MendozaRichard A Firtel

❮ Previous
Next ❯

Citations

Mar 17, 2007·Molecular Genetics and Genomics : MGG·Koen Houthoofd, Jacques R Vanfleteren
Aug 7, 2013·Journal of the American Chemical Society·Chris J VickersDennis W Wolan
Apr 9, 2008·Oncogene·D R Calnan, A Brunet
Apr 9, 2008·Oncogene·L Partridge, J C Brüning
Apr 9, 2008·Oncogene·B M Th Burgering
Apr 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Dona C LoveJohn A Hanover
Sep 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Young-Sil YoonSeung-Hoi Koo
Feb 7, 2008·Journal of Toxicology and Environmental Health. Part a·Wonsuk Yang, Evelyn Tiffany-Castiglioni
Aug 19, 2008·Antioxidants & Redox Signaling·Saghi Ghaffari
Aug 5, 2009·Antioxidants & Redox Signaling·Shazib PervaizSaghi Ghaffari
Aug 3, 2010·Antioxidants & Redox Signaling·Kelvin YenHeidi A Tissenbaum
Mar 5, 2011·Human Molecular Genetics·Richard I TuxworthGuy Tear
Mar 29, 2011·Cold Spring Harbor Perspectives in Biology·Rebecca C Taylor, Andrew Dillin
Nov 17, 2007·Genes & Development·Andrew V SamuelsonGary Ruvkun
Aug 19, 2008·Genes & Development·Nicole Fielenbach, Adam Antebi
Mar 14, 2007·Molecular and Cellular Biology·Michelle C MendozaRichard A Firtel
Nov 28, 2013·Annual Review of Genetics·Dennis H Kim
Jan 10, 2008·Annual Review of Cell and Developmental Biology·Susan E Mango
Nov 20, 2009·PLoS Biology·Minhua ZhangCharles V Mobbs
Apr 7, 2007·PLoS Genetics·Sean P Curran, Gary Ruvkun
Oct 3, 2007·PLoS Genetics·Adam Antebi
Sep 8, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·J Alex ParkerChristian Neri
Apr 30, 2014·International Archives of Allergy and Immunology·Alina NeunkirchnerWinfried F Pickl
May 17, 2014·Longevity & Healthspan·Ankita BansalHeidi A Tissenbaum
Apr 24, 2014·Ageing Research Reviews·Devika Garg, Stephen M Cohen
Nov 30, 2012·Annual Review of Physiology·David Gems, Linda Partridge
Oct 3, 2007·The Journal of Cell Biology·Seung-Hwan KimW Matthew Michael
Sep 4, 2012·Trends in Endocrinology and Metabolism : TEM·Louis R Lapierre, Malene Hansen
Oct 20, 2009·Bioorganic & Medicinal Chemistry·Ming-Hong ChuangChi-Huey Wong
Aug 4, 2009·Trends in Endocrinology and Metabolism : TEM·Siler H Panowski, Andrew Dillin
May 26, 2009·Biochimica Et Biophysica Acta·Robert J Shmookler ReisSrinivas Ayyadevara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.