Smokeless tobacco reduction: preliminary study of tobacco-free snuff versus no snuff

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
D K HatsukamiStephen S Hecht

Abstract

This preliminary study examined the effects of tobacco-free snuff (intervention, n = 52) compared with no snuff (control, n = 54) for reducing tobacco use among smokeless tobacco (ST) users not interested in quitting. Both groups received behavioral instructions, and intervention subjects received tobacco-free snuff for 8 weeks. Participants were required to reduce their intake by 50% during the first 4 weeks and by 75% during the subsequent 4 weeks. Follow-up occurred at 12 weeks. Significant reductions were observed from baseline to week 8 (end of treatment) for both treatment groups in the amount of ST use (tins/week and dips/day, p<.001); mean urinary cotinine (p<.001); and mean urinary total NNAL, a carcinogen biomarker (p<.001). At week 8 the intervention resulted in a lower mean total NNAL (p = .048). Compared with the control condition, the intervention resulted in a higher percentage of subjects achieving at least a 50% reduction in cotinine (p = .046) and total NNAL (p = .002) at the end of treatment, more quit attempts (p = .030), and a longer mean duration of abstinence (p = .013) through follow-up. An ST reduction intervention incorporating tobacco-free snuff could potentially reduce risk for ST-related disease bey...Continue Reading

Citations

Jun 8, 2010·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jon O EbbertDorothy K Hatsukami
Aug 21, 2010·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jon O EbbertDarrell R Schroeder
Jan 6, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Katherine R SchillerDorothy K Hatsukami
Apr 25, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Andrew J OliverDorothy K Hatsukami
Sep 1, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Shari P FeirmanTianjing Li
Oct 27, 2015·The Cochrane Database of Systematic Reviews·Jon O EbbertLindsay F Stead
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Nicola Lindson-HawleyTim Lancaster
Dec 20, 2014·Cancer Prevention Research·Dorothy K HatsukamiStephen S Hecht

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