Smokers with opioid use disorder may have worse drug use outcomes after varenicline than nicotine replacement

Journal of Substance Abuse Treatment
Rosemarie A MartinJennifer W Tidey

Abstract

Smokers with opioid use disorder (OUD) have little success with smoking cessation, possibly due to interactions between nicotine and opioid receptor systems. Smokers with OUD versus non-opioid substance use disorders (NOUD) have not been compared for response to smoking treatment. Data to make this comparison came from our previous study of 12 weeks (plus dose run-up) of varenicline (VAR) versus 12 weeks of nicotine patch (NRT), in a double-placebo design. The current study reports secondary analyses comparing smokers with OUD (n = 47) and NOUD (n = 90) on pretreatment smoking, alcohol and drug use, intolerance of physical discomfort, smoking medication adherence, and 3- and 6-month smoking and substance use outcomes (by VAR versus NRT). Smokers with OUD did not differ on pretreatment alcohol or smoking measures while reporting significantly more drug use days. Smokers with OUD versus NOUD had significantly fewer days adherent to VAR or placebo capsules but not to patches, and were more tolerant of physical discomfort. While smoking and heavy drinking days at follow-ups did not differ by diagnosis, smokers with OUD had significantly more drug use days in months 4-6 when assigned to VAR (16.4 days) than to NRT (8.1 days). NRT mi...Continue Reading

Citations

Feb 29, 2020·CNS Drugs·Cynthia VladShadi Nahvi
Jun 5, 2020·The Journal of Behavioral Health Services & Research·Chad D Morris, Christine E Garver-Apgar
Apr 9, 2021·Peptides·Richard J Bodnar

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