Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored

PloS One
Beena Elizabeth ThomasCTRIUMPH-RePORT India Study

Abstract

More than 20% of tuberculosis (TB) disease worldwide may be attributable to smoking and alcohol abuse. India is the second largest consumer of tobacco products, a major consumer of alcohol particularly among males, and has the highest burden of TB globally. The impact of increasing tobacco dose, relevance of alcohol misuse and past versus current or never smoking status on TB treatment outcomes remain inadequately defined. We conducted a multi-centric prospective cohort study of newly diagnosed adult pulmonary TB patients initiated on TB treatment and followed for a minimum of 6 months to assess the impact of smoking status with or without alcohol abuse on treatment outcomes. Smokers were defined as never smokers, past smokers or current smokers. Alcohol Use Disorder Identification Test (AUDIT) scores were used to assess alcohol misuse. The association between smoking status and treatment outcomes was assessed in univariate and multivariate random effects poisson regression models. Of 455 enrolled, 129 (28%) had a history of smoking with 94 (20%) current smokers and 35 (8%) past smokers. Unfavourable treatment outcomes were significantly higher among past and current smokers as compared to never smokers. Specifically, the risk ...Continue Reading

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Citations

Dec 28, 2019·PloS One·Ninfa Marlen Chaves TorresEduardo Martins Netto
Jan 4, 2021·Substance Abuse Treatment, Prevention, and Policy·Mogesie NechoAmare Muche
Dec 12, 2020·BMC Musculoskeletal Disorders·Natalia Chu-Oi CiangHo Yin Chung
Jun 2, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Haoxiang LinChun Chang
Jul 13, 2021·Open Forum Infectious Diseases·Ramnath SubbaramanJessica E Haberer
Aug 1, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yan LinGrania Brigden

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