Smoking and amyotrophic lateral sclerosis: A mendelian randomization study

Annals of Neurology
Yiqiang Zhan, Fang Fang

Abstract

In this study, we examined the potential causal effect of smoking on amyotrophic lateral sclerosis (ALS) using the Project MinE data involving 12,577 patients with ALS and 23,475 controls in a Mendelian randomization (MR) framework. The MR approach has the potential to investigate a causal relationship between a risk factor and a disease, avoiding confounding and information bias that often present in conventional epidemiological studies. We found that smokers had a higher risk of ALS compared to never smokers. Our study thus provides evidence for a causal relationship between smoking and ALS. Ann Neurol 2019;85:482-484.

References

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Citations

Jun 28, 2019·Neurology·Carmel Armon, Bryan J Traynor
Jul 31, 2019·Current Opinion in Neurology·Elisa Longinetti, Fang Fang
Oct 18, 2019·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Tim VlaarFrédéric Moisan
Jun 13, 2020·Journal of Neurology·Marijne Vandebergh, An Goris
Aug 28, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Sarah Opie-MartinAmmar Al-Chalabi
Feb 7, 2021·Diagnostics·Ivana Štětkářová, Edvard Ehler
Jun 4, 2021·Journal of Internal Medicine·Jiangwei SunFang Fang
Jul 11, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xu ChenFang Fang
Apr 30, 2021·G3 : Genes - Genomes - Genetics·Marko MelnickMercedes Prudencio

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