Smoking and matrix metalloproteinases, neutrophil elastase and myeloperoxidase in chronic periodontitis

Oral Diseases
O OzçakaN Buduneli

Abstract

To investigate possible relationship between smoking and serum concentrations of matrix metalloproteinase-8,-9 (MMP-8, MMP-9), tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), neutrophil elastase (NE), myeloperoxidase (MPO) in chronic periodontitis (CP) patients relative to periodontally healthy subjects. Serum samples were obtained from 111 subjects before initiation of any periodontal intervention. Fifty-five CP patients (39 non-smokers, 16 smokers) and 56 periodontally healthy subjects (39 non-smokers, 17 smokers) were recruited. Serum concentrations of MMP-8 were determined by IFMA and MPO, MMP-9, TIMP-1, NE concentrations by ELISA. ANCOVA and Pearson correlation analysis was utilized for statistical analysis. Serum MPO, NE concentrations were higher in smoker CP than non-smoker CP patients (P=0.002 and P<0.001, respectively), whereas these were similar in smoker, non-smoker periodontally healthy groups (P > 0.05). TIMP-1 concentration was higher in non-smoker CP than smoker CP group (P<0.05). MMP-9/TIMP-1 ratios were higher in smoker CP than non-smoker CP group (P=0.01). MMP-8 concentrations, MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios in CP group were not significantly different from those in periodontally healthy group...Continue Reading

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Citations

Apr 19, 2012·Journal of Periodontology·Özgün ÖzçakaNurcan Buduneli
Jun 4, 2013·Journal of Periodontology·Başak KavalNurcan Buduneli
Nov 17, 2012·Journal of the Neurological Sciences·Marcus W KochV Wee Yong
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Nov 1, 2018·Brazilian Oral Research·Rahşan Atasoy ŞentürkBinnaz Handan Özdemir
Aug 14, 2020·Journal of Periodontal Research·Zeynep Pinar Keles YucelTimo Sorsa
Oct 12, 2018·International Journal of Dentistry·Ahmed Al-MajidTimo Sorsa
Mar 9, 2018·Journal of Periodontal Research·E R HerreroW Teughels
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Feb 2, 2021·Frontiers in Physiology·Oindrila PaulShampa Chatterjee
Aug 8, 2021·International Journal of Environmental Research and Public Health·Rumeysa Omer-CihangirFunda Yalcin

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