Smoking and other factors associated with short-term partial remission of Type 1 diabetes in adults

Diabetic Medicine : a Journal of the British Diabetic Association
S PilacinskiB Wierusz-Wysocka

Abstract

The duration of partial remission of Type 1 diabetes is associated with the degree of initial metabolic disturbance and features of insulin resistance. Cigarette smoking decreases insulin sensitivity, but its influence on the length of remission is unknown. Therefore, this study assessed the relationship between cigarette smoking and duration of partial remission in adults with newly diagnosed Type 1 diabetes. We recruited 149 patients (48 women and 101 men, aged 16-35 years, median age 25 years), admitted to a teaching hospital with newly diagnosed Type 1 diabetes and followed them for a median period of 1 year and 9 months. We introduced intensive insulin therapy in multiple injections (basal-bolus) in all patients. We defined partial remission as an insulin dose of ≤ 0.3 U/kg body weight/24 h, an HbA(1c) value < 53 mmol/mol (7.0%) and a random serum C-peptide concentration over 0.5 ng/ml. Cigarette smoking was determined by self-report. Of 149 patients, 68 (46%) fulfilled the criteria for partial remission at 1 year after diagnosis of diabetes. Fewer patients who were in partial remission at 1 year smoked (19/68, 28%) than did patients that were not in partial remission (41/81, 51%). In logistic regression analyses, non-smok...Continue Reading

References

May 15, 2018·Oral Diseases·Mateusz TarnowskiMarzena Wyganowska-Swiatkowska
Feb 5, 2020·Diabetes Technology & Therapeutics·Pawel NiedzwieckiD A Zozulinska-Ziolkiewicz

Citations

May 1, 1992·Diabetes Research and Clinical Practice·E GuastamacchiaG M Nardelli
Feb 1, 1990·Journal of Internal Medicine·B M LundmanA Norberg
Jul 24, 1986·The New England Journal of Medicine·H Yki-Järvinen, V A Koivisto
Sep 1, 1986·Metabolism: Clinical and Experimental·E HelveV A Koivisto
Mar 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·M Berger, I Mühlhauser
Aug 1, 1994·Research in Nursing & Health·D Haire-JoshuE B Fisher
Nov 14, 1997·The Journal of Clinical Endocrinology and Metabolism·G TargherE Bonora
Mar 19, 1999·Journal of Internal Medicine·A SchölinE Björk
Aug 29, 2000·Diabetes Research and Clinical Practice·U Stenström, P Andersson
May 1, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·E BöberA Büyükgebiz
Apr 20, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·A SchölinE Björk
Jun 30, 2004·Diabetes & Metabolism·P M NilssonSteering Committee of the Swedish National Diabetes Register
Feb 4, 2005·Metabolism: Clinical and Experimental·Hiroyasu YoshikawaValdemar Grill
Jul 18, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·A T AhmedJ Liu
Mar 27, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·N C SchlootT Mandrup-Poulsen
Sep 23, 2008·The Journal of Pediatrics·Sabine E HoferDPV-Wiss. Study Group

Related Concepts

Insulin Sensitivity
Remission, Spontaneous
C-Peptide
Weighing Patient
Insulin Resistance
Insulin C-peptide Measurement
Cancer Remission
Novolin
Diabetic Ketoacidosis
Diabetes Mellitus, Insulin-Dependent

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.