Smoking and outcomes in kidney transplant recipients: a post hoc survival analysis of the FAVORIT trial

International Journal of Nephrology and Renovascular Disease
Larry A WeinrauchJohn A D'Elia

Abstract

Tobacco use remains an international health problem with between 10% and 40% of adults currently using tobacco. Given the rising number of patients either awaiting or having received a kidney transplant and the absence of smoking cessation as the criterion for transplantation in guidelines, we explored the association between smoking status and clinical outcomes in kidney transplant recipients. In this post hoc analysis of the Folic Acid for Vascular Outcome Reduction in Transplant trial, the associations between smoking status, defined as never having smoked, formerly or currently smoking, and both all-cause mortality and graft survival were assessed using Cox proportional hazards models. Fatal events were centrally adjudicated into prespecified categories: all-cause, cardiovascular and non-cardiovascular causes. Graft loss was defined as return to dialysis or retransplantation. Clinical Trials URL: http://www.clinicaltrials.gov/show/NCT00064753. Among 4110 transplant recipients, there were 451 current smokers and 1611 former smokers. The mortality rate per 100 patient-years was 4.0 (71 deaths) for smokers, 3.5 (226 deaths) for former smokers and 2.4 (116 deaths) for never smokers. Hazard ratio for mortality for current smoker...Continue Reading

Citations

Nov 9, 2018·Journal of Nephrology·Paul A DevineAlexander P Maxwell
Apr 26, 2020·Journal of Clinical Medicine·Charat ThongprayoonWisit Cheungpasitporn
May 1, 2021·Journal of Clinical Medicine·Madhivanan Elango, Vassilios Papalois
Jun 6, 2020·Journal of the American College of Cardiology·Larry A Weinrauch, John A D'Elia
Jul 3, 2021·Journal of Clinical Medicine·Prasanti Alekhya KottaVassilios Papalois
Apr 11, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Stefan ScheidlHorst Olschewski
Oct 13, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Hee-Yeon JungChan-Duck Kim

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Methods Mentioned

BETA
coronary
amputation

Software Mentioned

STATA
FAVORIT

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