Smoking as a risk factor for renal injury in essential hypertension

Nephron. Clinical Practice
Leszek TylickiWalter H Horl

Abstract

Smoking is an important player in the pathogenesis of hypertensive nephropathy. To shed more light on this issue, we performed a case-control cross-sectional study and stratification analyses to evaluate the influence of smoking on surrogate markers of kidney injury and oxidative stress in patients supposed to have hypertensive nephropathy. The dependence of kidney lesions on the 'extent' of smoking was determined as well. 82 patients with essential hypertension and micro- or macro-albuminuria were recruited. The control group consisted of 41 sex- and age-matched healthy individuals. Urine albumin creatinine ratio and plasma von Willebrand factor activity were analysed as markers of endothelial injury. N-acetyl-beta-D-glucosaminidase, transforming growth factor-beta1 and 15-isoprostane F2t urine excretions were regarded as markers of tubular dysfunction, renal fibrosis and oxidative stress, respectively. Patients' smoking habits were recorded and categorized on the basis of a self-administered questionnaire. In multivariate regression analysis, the independent associations between smoking and urine albumin (p < 0.05; beta = 0.27), von Willebrand factor activity (p < 0.05; beta = 0.29) and urine isoprostanes (p < 0.05; beta = 0....Continue Reading

References

Jan 1, 1976·Nephron·E R Fisher, J Pirog
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·J Thyberg
Mar 16, 1989·The New England Journal of Medicine·S G RostandH P Dustan
Jul 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·J Cluette-BrownJ Hojnacki
Jul 1, 1984·Clinical Pharmacology and Therapeutics·N L BenowitzP Jacob
Jan 4, 1996·The New England Journal of Medicine·M J KlagJ Stamler
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·H S KimO Smithies
Jul 1, 1994·Journal of Diabetes and Its Complications·A MimranJ M Halimi
May 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·I Mühlhauser
Jan 18, 1996·The New England Journal of Medicine·D S CelermajerJ E Deanfield
Jan 15, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A J BleyerR G Appel
Apr 29, 1998·Journal of the American Society of Nephrology : JASN·G GambaroB Baggio
Apr 20, 1999·Mineral and Electrolyte Metabolism·B RutkowskiW Lysiak-Szydlowska
Mar 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M RegaladoD E Wesson
Apr 12, 2000·Kidney International·J B Stokes
Oct 18, 2000·Annals of Internal Medicine·S J Pinto-SietsmaP E de Jong
Nov 16, 2001·Journal of the American College of Surgeons·S KilaruB E Sumpio
Aug 21, 2002·Current Opinion in Nephrology and Hypertension·Stephan R Orth, Eberhard Ritz
Feb 19, 2003·Kidney & Blood Pressure Research·Leszek TylickiWalter H Hörl
Nov 12, 2003·Kidney & Blood Pressure Research·Leszek TylickiWalter H Hörl
Dec 20, 2003·Journal of the American Society of Nephrology : JASN·Stephan R Orth

❮ Previous
Next ❯

Citations

Sep 30, 2008·Antioxidants & Redox Signaling·Ravi NistalaJames R Sowers
May 3, 2011·Journal of Atherosclerosis and Thrombosis·Tomoko UsuiYutaka Kiyohara
May 24, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Claudio Ponticelli, Giorgio Graziani
Oct 27, 2016·Journal of Nephrology·Francesca ViazziRoberto Pontremoli
Feb 13, 2019·Clinical Kidney Journal·Baris AfsarMehmet Kanbay
Apr 20, 2021·Toxicological Research·Solange BandieraMauricio S Nin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

© 2022 Meta ULC. All rights reserved