Smoking at time of CIS increases the risk of clinically definite multiple sclerosis

Journal of Neurology
Roos M van der Vuurst de VriesRogier Q Hintzen

Abstract

Cigarette smoking is a modifiable risk factor that influences the disease course of patients with multiple sclerosis (MS). However, in patients with a clinically isolated syndrome (CIS), there are conflicting results about the association between smoking and the risk of a subsequent MS diagnosis. The aim of this study was to determine the risk of clinically definite MS (CDMS) in smoking and non-smoking patients at time of a first demyelinating event. Two hundred and fifty patients, aged 18-50 years, were included in our prospective CIS cohort. At time of the first neurological symptoms, patients completed a questionnaire about smoking habits. Cox regression analyses were performed to calculate univariate and multivariate hazard ratios for CDMS diagnosis in smoking and non-smoking CIS patients. One hundred and fourteen (46%) CIS patients were diagnosed with CDMS during a mean follow-up of 58 months. In total, 79 (32%) patients smoked at time of CIS. Sixty-seven % of the smoking CIS patients were diagnosed with CDMS during follow-up compared to 36% of the non-smoking CIS patients (p < 0.001). Smoking at time of CIS was an independent predictor for CDMS diagnosis (HR 2.3; p = 0.002). Non-smoking CIS patients who had a history of s...Continue Reading

References

Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Apr 1, 1997·Journal of Consulting and Clinical Psychology·S ShiffmanJ D Kassel
Mar 11, 2005·Brain : a Journal of Neurology·Miguel A HernánHershel Jick
Feb 14, 2007·Neurology·Ana-Luiza SayaoHelen Tremlett
Jul 18, 2008·Multiple Sclerosis : Clinical and Laboratory Research·F Di PauliT Berger
Sep 23, 2008·Multiple Sclerosis : Clinical and Laboratory Research·D H MillerC H Polman
Oct 31, 2008·Lancet·Alastair Compston, Alasdair Coles
Apr 3, 2009·Brain : a Journal of Neurology·Josa M FrischerHans Lassmann
Nov 11, 2009·Neurology·Kassandra L MungerAlberto Ascherio
Jan 1, 2010·Journal of Autoimmunity·Yoav ArnsonHoward Amital
Jan 21, 2011·PloS One·Adam E HandelSreeram V Ramagopalan
Feb 10, 2011·Brain : a Journal of Neurology·Anna Karin HedströmLars Alfredsson
Mar 5, 2011·Multiple Sclerosis : Clinical and Laboratory Research·A K HedströmL Alfredsson
Jan 24, 2012·Lancet Neurology·David H MillerOlga Ciccarelli
Jan 11, 2013·The International Journal of Neuroscience·Adalet ArikanogluMefkure Eraksoy
Jan 22, 2013·Lancet Neurology·Jimmy L Huynh, Patrizia Casaccia
Jun 13, 2013·Brain : a Journal of Neurology·Ali ManouchehriniaCris S Constantinescu
Oct 23, 2013·European Journal of Epidemiology·Anna Karin HedströmLars Alfredsson
Jan 8, 2014·JAMA Neurology·Anna Karin HedströmLars Alfredsson
Oct 18, 2014·International Journal of Epidemiology·Anna Karin HedströmLars Alfredsson
Apr 14, 2015·Journal of Neuroimmunology·Jorge Correale, Mauricio F Farez
Apr 23, 2015·Brain : a Journal of Neurology·Mar TintoreXavier Montalban
Sep 9, 2015·JAMA Neurology·Ryan RamanujamJan Hillert
Apr 7, 2017·European Journal of Clinical Investigation·Mathilde VersiniHoward Amital
Apr 13, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Radu TanasescuAli Manouchehrinia
Oct 23, 2017·Multiple Sclerosis and Related Disorders·Michelle L Degelman, Katya M Herman

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Citations

May 23, 2019·Neurodegenerative Disease Management·Dejan JakimovskiRobert Zivadinov
Dec 17, 2019·JAMA Neurology·Mattia Rosso, Tanuja Chitnis
Mar 31, 2020·Acta neurologica Belgica·Turhan KahramanUNKNOWN Multiple Sclerosis Research Group
Aug 18, 2018·Current Nutrition Reports·Ilana Katz Sand
Feb 6, 2020·Journal of Central Nervous System Disease·Eiman Ma Mohammed
Feb 18, 2020·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Devon S ConwayLe H Hua
Dec 10, 2020·Multiple Sclerosis and Related Disorders·Hamza CobanJaime Imitola
Oct 29, 2020·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Carrie M HershDevon Conway
Dec 29, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Christopher Martin AllenNikos Evangelou
Sep 9, 2021·Expert Review of Neurotherapeutics·Amin ZarghamiBruce V Taylor
May 31, 2020·Multiple Sclerosis and Related Disorders·Serhan SevimDerya Kaya

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