Smoking cessation, weight gain, and DRD4 -521 genotype

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Marcus R MunafòElaine C Johnstone

Abstract

We investigated change in body mass index following long-term smoking cessation in a representative cohort of treatment-seeking heavy smokers in the United Kingdom, to determine the extent of long-term weight gain in successful quitters versus continuing smokers. We further investigated whether DRD4 genotype moderated any weight gain in either group. Smoking cessation was associated with an increase in BMI, and persisted up to 8 years after smoking cessation. Ex-smokers at 8-year follow-up weighed over 2.5 kg/m(3) more on average than they did at baseline, while participants who were smokers at both baseline and 8-year follow-up did not demonstrate any change in BMI. We did not observe an interaction between smoking status and DRD4 genotype. However, independently of the weight gain among those who stopped smoking during the course of the study, DRD4 genotype was significantly associated with BMI, with possession of the -521 C-allele associated with increased BMI. The magnitude of increase in BMI following smoking cessation, and the persistence of this change at 8-year follow-up, suggests that health benefits associated with smoking cessation may to some extent be negated by the detrimental effects on health of associated weigh...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jan 1, 1995·American Journal of Public Health·G E Swan, D Carmelli
Jul 1, 1997·Addictive Behaviors·K A GendallC M Bulik
May 18, 1999·Biochemical and Biophysical Research Communications·Y OkuyamaT Arinami
Mar 23, 2000·Eating and Weight Disorders : EWD·W S PostonJ P Foreyt
Dec 6, 2000·Progress in Brain Research·D E Comings, K Blum
Mar 10, 2001·Appetite·L Christensen, L Pettijohn
Mar 22, 2001·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·C S PomerleauA J Stewart
Aug 10, 2001·Journal of Consulting and Clinical Psychology·B BorrelliG Papandonatos
Nov 10, 2001·Science·B A Barres, S J Smith
Jul 20, 2002·Physiology & Behavior·Michel Cabanac, Patrick Frankham
Sep 5, 2002·American Journal of Medical Genetics·J A SchinkaF C Crawford
Nov 19, 2002·Journal of Neurobiology·Young-Hwan JoLorna W Role
Nov 20, 2002·Comprehensive Psychiatry·Secondo FassinoGiovanni Giacomo Rovera
Apr 8, 2003·Current Topics in Medicinal Chemistry·Ming D LiOzlen Konu
Apr 22, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M OkashaD Gunnell
May 29, 2003·Current Drug Targets. CNS and Neurological Disorders·David J K Balfour
Nov 1, 2003·Pharmacology, Biochemistry, and Behavior·Bonnie SpringJessica Werth
Dec 23, 2003·Journal of General Internal Medicine·John R Hughes
Apr 13, 2004·Pharmacogenetics·Elaine C JohnstoneRobert T Walton
Apr 17, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C FilozofA Fernández-Cruz
May 13, 2004·Psychopharmacology·Caryn LermanLeonard H Epstein
Jun 24, 2004·The American Journal of Clinical Nutrition·Leonard H EpsteinCaryn Lerman
Jun 24, 2004·BMJ : British Medical Journal·Richard DollIsabelle Sutherland
Jan 4, 2005·Neuropsychobiology·Marko ElovainioLiisa Keltikangas-Jarvinen
May 20, 2005·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·U JohnU Hapke

❮ Previous
Next ❯

Citations

Oct 5, 2007·Current Psychiatry Reports·Robert A SchnollCaryn Lerman
Mar 17, 2010·Journal of Addiction Medicine·Katherine A Vanbuskirk, Marc N Potenza
Jan 22, 2014·Pharmacogenomics·Aryeh I HermanMehmet Sofuoglu
Feb 24, 2007·Preventive Medicine·Anthony J AlbergMatthew J Carpenter
Jan 15, 2008·Addiction·Marcus R Munafò, Elaine C Johnstone
Jul 12, 2008·Alcoholism, Clinical and Experimental Research·Doug Hyun HanPerry F Renshaw
Jan 17, 2007·The Pharmacogenomics Journal·M R MunafòE C Johnstone
May 16, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Marcus R MunafòYoav Ben-Shlomo
Oct 27, 2015·Psychopharmacology·Paul T HarrellDavid E Evans
Mar 3, 2011·Addiction Biology·Jessica E SturgessDaniel J Müller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
J P BurkeM P Stern
The Pharmacogenomics Journal
Marcus R MunafòElaine C Johnstone
© 2021 Meta ULC. All rights reserved