Smoking, disease characteristics and serum cytokine levels in patients with primary Sjögren's syndrome

Rheumatology International
Peter OlssonThomas Mandl

Abstract

Smoking affects several disease processes. Epidemiological studies have previously found a negative association between primary Sjögren's syndrome (pSS) and smoking. The aim of this study was to examine whether markers of disease activity and cytokine expression in pSS patients differ between ever and never smokers. Fifty-one consecutive pSS patients and 33 population controls were included in the study. Clinical and standard laboratory parameters were registered. Serum cytokines (IL-1β, IL-2, IL-3, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, IL-18, IL-33, IFN-α, IFN-γ, TNF-α, EGF, BAFF, Fas-ligand, RANTES, TGF-β1) were assessed. A positive lip biopsy was less prevalent among ever smoking patients compared to never smokers (81 vs 100%; p = 0.03). However, except for TNF-α, which was higher in ever smokers, no differences in cytokine levels were found when comparing ever and never smoking pSS patients. Furthermore, no significant differences were found between ever and never smoking patients in the ESSDAI total score, IgG levels, or complement levels. However, IL-6, IL-12, IL-17 and IL-18 were significantly increased in pSS patients compared to controls. In this study, a negative association between ever smoking and positive lip biop...Continue Reading

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Citations

Jan 18, 2021·International Journal of Dermatology·Noriko KatoDaisuke Watanabe
Nov 3, 2021·Lupus Science & Medicine·Warren David RaymondJohannes Cornelis Nossent

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Methods Mentioned

BETA
biopsies
biopsy
glycosylations

Software Mentioned

Scale
Meso
Discovery Workbench
SPSS

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