Smoking, Gender, and Overweight Are Important Influencing Factors on Monocytic HLA-DR before and after Major Cancer Surgery

BioMed Research International
Gunnar LachmannClaudia D Spies

Abstract

Monocytic human leukocyte antigen D related (mHLA-DR) is essential for antigen-presentation. Downregulation of mHLA-DR emerged as a general biomarker of impaired immunity seen in patients with sepsis and pneumonia and after major surgery. Influencing factors of mHLA-DR such as age, overweight, diabetes, smoking, and gender remain unclear. We analyzed 20 patients after esophageal or pancreatic resection of a prospective, randomized, placebo-controlled, double-blind trial (placebo group). mHLA-DR was determined from day of surgery (od) until postoperative day (pod) 5. Statistical analyses were performed using multivariate generalized estimating equation analyses (GEE), nonparametric multivariate analysis of longitudinal data, and univariate post hoc nonparametric Mann-Whitney tests. In GEE, smoking and gender were confirmed as significant influencing factors over time. Univariate analyses of mHLA-DR between smokers and nonsmokers showed lower preoperative levels (p = 0.010) and a trend towards lower levels on pod5 (p = 0.056) in smokers. Lower mHLA-DR was seen in men on pod3 (p = 0.038) and on pod5 (p = 0.026). Overweight patients (BMI > 25 kg/m2) had lower levels of mHLA-DR on pod3 (p = 0.039) and pod4 (p = 0.047). Smoking is an...Continue Reading

References

Sep 16, 1991·The American Journal of Medicine·R A GaribaldiT Lerer
Feb 1, 1988·American Journal of Infection Control·D E LilienfeldJ S McLaughlin
Nov 20, 1998·Archives of Surgery·J SchröderF Stüber
Sep 16, 1999·Archives of Surgery·P J OffnerW L Biffl
Oct 8, 1999·The New England Journal of Medicine·E E CalleC W Heath
Dec 11, 1999·Archives of Surgery·S R EachempatiP S Barie
Mar 22, 2000·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·K WolkR Sabat
May 8, 2001·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·S OnoH Mochizuki
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Thierry Fumeaux, Jérôme Pugin
Dec 24, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Robert F Grimble
Jun 13, 2003·Intensive Care Medicine·Wolfgang OczenskiRobert D Fitzgerald
Nov 8, 2003·Intensive Care Medicine·Sascha FlohéChristian Waydhas
Dec 31, 2003·Trends in Immunology·Paresh DandonaArindam Bandyopadhyay
Mar 19, 2004·American Journal of Respiratory and Critical Care Medicine·Yves Le TulzoBernard Drénou
Apr 17, 2004·Shock·Christopher J GannonLena M Napolitano
Feb 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN Infectious Diseases Society of America
Jun 3, 2006·Intensive Care Medicine·Thierry Fumeaux, Jérôme Pugin
Sep 8, 2006·World Journal of Surgery·Olumuyiwa A BamgbadePema Dorje
Sep 19, 2006·Shock·Rosanna Di PaolaSalvatore Cuzzocrea
Jan 4, 2008·The Journal of Bone and Joint Surgery. American Volume·Margaret A OlsenVictoria J Fraser
Feb 19, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T ShimazuI Tsuji
Jul 16, 2009·Critical Care Medicine·Alain CombesJean Chastre
Dec 24, 2009·Critical Care Medicine·Alawi LuetzClaudia D Spies
Nov 26, 2010·Critical Care : the Official Journal of the Critical Care Forum·Aurélie CheronGuillaume Monneret
Jun 23, 2011·Critical Care : the Official Journal of the Critical Care Forum·Irit NachtigallClaudia Spies
Sep 22, 2011·Critical Care : the Official Journal of the Critical Care Forum·Jian-Feng WuXiang-Dong Guan
Oct 8, 2013·Critical Care : the Official Journal of the Critical Care Forum·Sara CajanderJan Källman
Oct 3, 2014·Journal of the National Cancer Institute·Meredith S ShielsAnil K Chaturvedi
Oct 18, 2014·International Journal of Epidemiology·Anna Karin HedströmLars Alfredsson
Feb 24, 2015·The European Respiratory Journal·Pieter S HiemstraRobert Bals
Mar 31, 2015·Cell·Jonathan R Brestoff, David Artis

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