Smoking-induced transient motor deterioration in a levodopa-treated patient with Parkinson's disease.

Journal of Neurology
Helen LingAndrew Lees

Abstract

We report a 53-year-old patient with Parkinson's disease who complained of transient worsening of motor symptoms after smoking a tobacco cigarette. She had been a chronic smoker of one packet of cigarettes a day for over 20 years. We objectively assessed her motor performance including repetitive finger tapping (RFT) speed using 3D kinematic recordings, timed finger tapping test (TFT) and Unified Parkinson's Disease Rating Scale (UPDRS) III before and after the administration of nicotine, and with and without levodopa. Nicotine was delivered by either smoking a cigarette or by intranasal nicotine spray. Without levodopa, acute deterioration in RFT speed was observed 10 min after both routes of nicotine administration. With levodopa, there was acute deterioration in RFT speed after smoking cigarette, followed by a delayed rebound improvement. However, the administration of nicotine spray led to immediate and sustained motor improvement without initial deterioration. UPDRS III and TFT showed similar trends of acute motor deterioration after either smoking or use of the spray without intake of levodopa. Transient motor worsening after smoking tobacco has been previously reported in only one patient with Parkinson's disease. The ob...Continue Reading

References

Nov 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·M Merello, A J Lees
Nov 1, 1986·Neurology·J A Baron
Feb 1, 1969·Journal of Neurology, Neurosurgery, and Psychiatry·J G Graham, D R Oppenheimer
Jun 1, 1966·Journal of Neurology, Neurosurgery, and Psychiatry·J Marshall, H Schnieden
Sep 1, 1994·Psychopharmacology·K O FagerströmF Stelson
Jul 1, 1993·Journal of the Neurological Sciences·A Ishikawa, T Miyatake
Oct 6, 1997·Internal Medicine·H NishimuraM Sugita
Dec 10, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·G EbersbachW Poewe
Dec 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Simon LemayMarc-André Bédard
Jul 16, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Okan DoguAndrew Singleton
Aug 28, 2004·Trends in Neurosciences·Maryka Quik
Nov 3, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Hasmet Ayhan HanagasiMurat Emre
Dec 29, 2006·Journal of Molecular Neuroscience : MN·Susan WonnacottIan W Jones
Oct 19, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G VillafaneP Maison
Jul 30, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Coro Paisán-RuizHenry Houlden
Jan 14, 2012·Clinical Neuropharmacology·Carlo Colosimo, Maurizio Inghilleri

❮ Previous
Next ❯

Citations

Jan 21, 2014·Expert Opinion on Drug Metabolism & Toxicology·Livia Dézsi, László Vécsei
Mar 19, 2013·Clinical Neuropharmacology·Win Thiri KyawMasahiro Nomoto
Jul 7, 2017·Translational Neurodegeneration·Chaoran MaXiang Gao
Jul 30, 2020·The American Journal of Clinical Nutrition·Chaoran MaXiang Gao
Jun 16, 2021·Journal of the Neurological Sciences·Shuichiro NeshigeHirofumi Maruyama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society
G EbersbachW Poewe
Expert Review of Clinical Pharmacology
Claire ThiriezPierre Cesaro
Movement Disorders : Official Journal of the Movement Disorder Society
Hasmet Ayhan HanagasiMurat Emre
Movement Disorders : Official Journal of the Movement Disorder Society
Maryka QuikDanhui Zhang
© 2021 Meta ULC. All rights reserved