Smoking is an independent association of squamous metaplasia in Chinese nasal polyps

International Forum of Allergy & Rhinology
Tian GaoDe Yun Wang

Abstract

Nasal polyposis demonstrates histological features of epithelial remodeling and variable inflammatory cellular infiltration. We studied a large series of Chinese nasal polyp (NP) samples to characterize these histological features and their associations with clinical characteristics. A detailed histological study of nasal polyposis was performed employing various histopathological techniques. A total of 153 intraoperative NP biopsies were analyzed histologically. Sections were examined under microscopy to determine the percentages of different types of inflammatory cells, and types of epithelial remodeling. Two systems of subtyping NPs based on inflammatory cell infiltration were assessed. These were correlated with patient characteristics. Epithelial remodeling patterns include epithelial hyperplasia (87.8% of specimens), goblet cell hyperplasia (53.2%), and squamous metaplasia (44.6%). Smoking was a strong independent association of squamous metaplasia (adjusted odds ratio [OR] 9.9; 95% confidence interval [CI], 4.2 to 22.9; p < 0.01). The most common inflammatory cells were neutrophils (median of 12.8%) and CD8+ T cells (12.8%), followed by macrophages (11.0%), CD4+ T cells (9.7%), eosinophils (8.6%), and mast cells (7.6%). ...Continue Reading

References

Feb 1, 1990·British Journal of Industrial Medicine·M BoysenA Reith
Jan 1, 1993·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·A Davidsson, H B Hellquist
May 1, 1996·American Journal of Respiratory Cell and Molecular Biology·J TesfaigziP S Wright
Apr 1, 1997·American Journal of Respiratory Cell and Molecular Biology·U A TemannJ A Rankin
Jun 6, 2000·American Journal of Respiratory Cell and Molecular Biology·J LouahedN C Nicolaides
Dec 28, 2002·American Journal of Respiratory and Critical Care Medicine·Atsuko KibeNobuyuki Hara
Feb 20, 2003·The Journal of Laryngology and Otology·Neil D BatemanTimothy J Woolford
Sep 18, 2004·Science·Alison A HumblesCraig Gerard
Feb 4, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jing HaoDe-Yun Wang
Jun 9, 2006·Pharmacology & Therapeutics·Mimi L K TangSimon G Royce
Oct 27, 2006·Proceedings of the American Thoracic Society·Scott H Randell
Apr 24, 2007·Current Allergy and Asthma Reports·Ruby Pawankar, Manabu Nonaka
Nov 28, 2007·Respiratory Research·Thérèse S LapperreUNKNOWN GLUCOLD Study Group
Jun 23, 2009·The Journal of Allergy and Clinical Immunology·Ping-Ping CaoZheng Liu
Aug 12, 2010·Disease Models & Mechanisms·Jason R RockBrigid L M Hogan
Mar 27, 2012·The Laryngoscope·Samy ElwanyIman Talaat
Mar 31, 2012·The Journal of Allergy and Clinical Immunology·Weiping WenUNKNOWN Nasal Health Group, China (NHGC)
Apr 2, 2013·The Journal of Allergy and Clinical Immunology·Joy HsuJayant M Pinto
May 29, 2013·American Journal of Rhinology & Allergy·Francisco de Borja CallejasJoaquim Mullol
Mar 22, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Tawakir KamaniOğuz Kuşçu
Mar 29, 2014·The Journal of Craniofacial Surgery·Zeynep Gökçen KuleAli Okan Gursel
Jul 11, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·S Hancer TecimerO Basut
Oct 15, 2014·The Journal of Allergy and Clinical Immunology·Mahboobeh MahdaviniaRobert P Schleimer
Feb 3, 2015·The Laryngoscope·Francisco de Borja CallejasJoaquim Mullol

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Citations

Jan 11, 2016·International Forum of Allergy & Rhinology·Robert C Kern
Apr 13, 2018·American Journal of Rhinology & Allergy·Ashley L HeilingoetterPete S Batra
May 22, 2018·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Z ChenD Y Wang
Feb 14, 2018·International Forum of Allergy & Rhinology·Sarah K WiseMark Zacharek
Nov 22, 2018·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Yang PengDe-Yun Wang
Dec 7, 2018·Current Opinion in Otolaryngology & Head and Neck Surgery·Aryan D Shay, Bobby A Tajudeen
Jul 17, 2019·Ear, Nose, & Throat Journal·Aleksandar PerićBiserka Vukomanović Đurđević

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