Smoking is associated with a high prevalence of microalbuminuria in hypertensive high-risk patients: data from I-SEARCH.

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Christian UkenaMichael Böhm

Abstract

Microalbuminuria (MAU) is a marker of endothelial dysfunction and a predictor of cardiovascular events. The effects of cigarette smoking on the prevalence of MAU in a high-risk population with arterial hypertension are unclear. The International Survey Evaluating Microalbuminuria Routinely by Cardiologists in patients with Hypertension (I-SEARCH) documented the clinical profile of 20,364 patients with arterial hypertension and cardiovascular risk factors. In this population, 13,690 patients had no history of smoking, 4,057 patients were former smokers and 2,617 patients were current smokers. The prevalence of MAU was associated with the smoking status. Consumption of 1-20 cigarettes per day leads to an increase of 6.8% in the prevalence of MAU compared to non-smokers (P < 0.001). Smoking of >20 cigarettes per day was associated with a 12.5% higher prevalence of MAU compared to non-smokers, while former smokers had a 4.7% higher prevalence of MAU. Multivariable analysis revealed that smoking was independently associated with MAU [odds ratio (OR) smoking vs. non-smoking 1.16; 95% confidence interval (CI) 1.01-1.33; P < 0.05]. Particularly, a consumption of >20 cigarettes per day was associated with high odds for MAU (OR 1.33; CI ...Continue Reading

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Citations

Apr 10, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Felix MahfoudMichael Böhm
Feb 20, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Monica LisiTommaso Gori
Sep 29, 2018·American Journal of Respiratory and Critical Care Medicine·Elizabeth C OelsnerSachin Yende
Dec 11, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xiaotong WangNanfang Li

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