Abstract
Microalbuminuria (MAU) is a marker of endothelial dysfunction and a predictor of cardiovascular events. The effects of cigarette smoking on the prevalence of MAU in a high-risk population with arterial hypertension are unclear. The International Survey Evaluating Microalbuminuria Routinely by Cardiologists in patients with Hypertension (I-SEARCH) documented the clinical profile of 20,364 patients with arterial hypertension and cardiovascular risk factors. In this population, 13,690 patients had no history of smoking, 4,057 patients were former smokers and 2,617 patients were current smokers. The prevalence of MAU was associated with the smoking status. Consumption of 1-20 cigarettes per day leads to an increase of 6.8% in the prevalence of MAU compared to non-smokers (P < 0.001). Smoking of >20 cigarettes per day was associated with a 12.5% higher prevalence of MAU compared to non-smokers, while former smokers had a 4.7% higher prevalence of MAU. Multivariable analysis revealed that smoking was independently associated with MAU [odds ratio (OR) smoking vs. non-smoking 1.16; 95% confidence interval (CI) 1.01-1.33; P < 0.05]. Particularly, a consumption of >20 cigarettes per day was associated with high odds for MAU (OR 1.33; CI ...Continue Reading
References
Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Mar 1, 1992·The Medical Clinics of North America·C B Sherman
Sep 1, 1990·Journal of Internal Medicine·G EkbergI Vaara
Apr 1, 1989·Diabetologia·T DeckertA Kofoed-Enevoldsen
Jun 1, 1986·The Journal of Clinical Investigation·R ZatzB M Brenner
Apr 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·W W PawlikR O Banks
Feb 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·J M StephensonE Lee
Jul 2, 1994·Lancet·R PedrinelliF De Negri
Aug 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·J J CouperP Henning
Jun 1, 1997·Kidney International·S R OrthR W Schrier
Oct 6, 1998·Archives of Internal Medicine·M CirilloN G De Santo
Dec 9, 1998·Journal of General Internal Medicine·P S MehlerR W Schrier
Oct 18, 2000·Annals of Internal Medicine·S J Pinto-SietsmaP E de Jong
Jul 31, 2001·JAMA : the Journal of the American Medical Association·H C GersteinUNKNOWN HOPE Study Investigators
Sep 22, 2001·The New England Journal of Medicine·E J LewisUNKNOWN Collaborative Study Group
Sep 22, 2001·The New England Journal of Medicine·H H ParvingUNKNOWN Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group
Mar 5, 2002·Journal of Hypertension·Kristian WachtellHans Ibsen
Apr 14, 2006·Kidney International·H-H ParvingUNKNOWN DEMAND investigators
Apr 25, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Roland E SchmiederMichael Böhm
Jun 15, 2007·Journal of Hypertension·Giuseppe ManciaUNKNOWN European Society of Cardiology
Sep 1, 2007·Journal of Hypertension·Giuseppe ManciaUNKNOWN ESH-ESC Task Force on the Management of Arterial Hypertension
Oct 9, 2007·Journal of Hypertension·Michael BöhmMassimo Volpe
Nov 21, 2007·Circulation·Scott D SolomonUNKNOWN Prevention of Events With ACE Inhibition (PEACE) Investigators
Dec 20, 2007·Journal of Hypertension·Michael BöhmMassimo Volpe
May 6, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christian WernerMichael Böhm
Apr 23, 2009·European Heart Journal·Michael BöhmMassimo Volpe
Citations
Apr 10, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Felix MahfoudMichael Böhm
Feb 20, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Monica LisiTommaso Gori
Mar 19, 2014·International Heart Journal·Lin YunJiamin Li
Sep 9, 2011·European Journal of Preventive Cardiology·Janine PössMichael Böhm
Sep 29, 2018·American Journal of Respiratory and Critical Care Medicine·Elizabeth C OelsnerSachin Yende
Dec 11, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xiaotong WangNanfang Li