Smoking-related interstitial lung disease

Deutsches Ärzteblatt International
Lars Hagmeyer, Winfried Randerath

Abstract

Smoking-related interstitial lung diseases (SR-ILDs) are a heterogeneous group of diseases with major clinical significance. Reliable epidemiological data are not yet available. Review of pertinent literature retrieved by a selective search in PubMed. The available data on many aspects of SR-ILDs are sparse, but recent studies on the pathophysiology and targeted treatment of these conditions have revealed ways in which clinical outcomes can be improved. Highresolution computerized tomography should be used for differential diagnosis; lung biopsy is often unnecessary. Oncogenic mutations play a role in the pathogenesis of pulmonary Langerhans-cell histiocytosis (PLCH). In the future, cladribine and vemurafenib may be treatment options for PLCH. Desquamative interstitial pneumonia (DIP) may be difficult to distinguish from respiratorybronchiolitis-associated interstitial lung disease (RB-ILD); DIP is treated with steroids and sometimes with immune suppressants. In idiopathic pulmonary fibrosis (IPF), the antifibrotic drugs pirfenidone and nintedanib can delay disease progression. Smoking is also a risk factor for combined pulmonary fibrosis and emphysema (CPFE), rheumatoid-arthritis-associated interstitial lung disease (RA-ILD), ...Continue Reading

References

Apr 13, 1978·The New England Journal of Medicine·C B CarringtonR G Gupta
Jan 1, 1991·Respiration; International Review of Thoracic Diseases·G FlusserD Heimer
Apr 1, 1987·The American Review of Respiratory Disease·J L MyersA L Katzenstein
Nov 20, 1971·British Medical Journal·R G RawboneK D Bagshawe
Feb 1, 1980·Chest·P C StillwellE G Harrison
Oct 1, 1993·The American Journal of Surgical Pathology·W D TravisR G Crystal
Jan 1, 1993·Respiration; International Review of Thoracic Diseases·N SchönfeldR Loddenkemper
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·K B BaumgartnerJ A Waldron
Jan 14, 1998·American Journal of Clinical Pathology·T V Colby
Jun 12, 1998·The European Respiratory Journal·G M VerledenM Demedts
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·M FartoukhG Simonneau
Apr 19, 2000·Thorax·A TaziA J Hance
Apr 20, 2001·The European Respiratory Journal·J H RyuR Vassallo
May 9, 2001·The American Journal of Surgical Pathology·S A YousemL M Weiss
Apr 30, 2002·The American Journal of Surgical Pathology·Mostafa FraigAnna-Luise A Katzenstein
Jul 18, 2002·American Journal of Respiratory and Critical Care Medicine·John F Seymour, Jeffrey J Presneill
Sep 1, 1965·The American Journal of Medicine·A A LIEBOWJ G BILLINGSLEY
Dec 23, 2004·JAMA : the Journal of the American Medical Association·Andrew F ShorrBruno P Petruccelli
Oct 6, 2005·The European Respiratory Journal·V CottinUNKNOWN Groupe d'Etude et de Recherche sur les Maladies Orphelines Pulmonaires (GERM O P)
Nov 25, 2005·The New England Journal of Medicine·Maurits DemedtsUNKNOWN IFIGENIA Study Group
Jan 3, 2006·The European Respiratory Journal·G RaghuC A Pellegrini
Mar 15, 2006·Transplantation·Gaëlle DauriatMichel Fournier
Jul 1, 2006·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuGerry Oster
Jul 5, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jonathan B OrensUNKNOWN Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation
Mar 16, 2007·Chest·Joshua PortnoyKevin K Brown
Mar 30, 2007·The New England Journal of Medicine·Mary Y ArmaniosJames E Loyd
May 29, 2007·The American Journal of Surgical Pathology·Lynette M ShollRobert F Padera
Jun 23, 2007·American Journal of Respiratory and Critical Care Medicine·Harold R CollardUNKNOWN Idiopathic Pulmonary Fibrosis Clinical Research Network Investigators
Aug 9, 2007·Respiration; International Review of Thoracic Diseases·Matthew D JankowichSharon Rounds
Nov 3, 2007·Seminars in Respiratory and Critical Care Medicine·Ulrich CostabelShinichiro Oshimo
Jan 19, 2008·American Journal of Respiratory and Critical Care Medicine·Yoshikazu InoueUNKNOWN Japanese Center of the Rare Lung Diseases Consortium
Oct 7, 2008·Journal of Medical Genetics·T MushirodaUNKNOWN Pirfenidone Clinical Study Group

❮ Previous
Next ❯

Citations

Jan 18, 2017·Deutsches Ärzteblatt International·Dominik BerlinerJohann Bauersachs
Jul 25, 2021·International Journal of Molecular Sciences·Omar HahadThomas Münzel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Radiographics : a Review Publication of the Radiological Society of North America, Inc
Anil K AttiliFernando J Martinez
European Respiratory Review : an Official Journal of the European Respiratory Society
Antonella CaminatiSergio Harari
Wiadomości lekarskie : organ Polskiego Towarzystwa Lekarskiego
Grzegorz GasiorMariola Ograbek-Król
© 2021 Meta ULC. All rights reserved