Smooth muscle cell-derived adenosine inhibits cell growth

Hypertension
R K DubeyE K Jackson

Abstract

Several endogenous factors generated within the vessel wall have been implicated in contributing to the vascular remodeling process associated with hypertension and atherosclerosis. Furthermore, substances generated by smooth muscle cells (SMCs) are known to regulate SMC proliferation in an autocrine fashion. Adenosine is a vasodilator synthesized by SMCs, and exogenous adenosine inhibits SMC proliferation. However, whether adenosine produced endogenously has antimitogenic effects is not known. Hence, we evaluated the effects of SMC-derived adenosine on 2.5% fetal calf serum-induced proliferation of rat aortic SMCs. SMC proliferation was assayed by measurement of DNA synthesis ([3H]thymidine incorporation) and cell counting. To determine the effects of endogenous adenosine on SMC proliferation, we stimulated growth-arrested SMCs with 2.5% fetal calf serum in the presence and absence of modulators of adenosine levels, including (1) erythro-9-(2-hydroxy-3-nonyl)adenine hydrochloride (EHNA; inhibits adenosine deaminase), (2) dipyridamole (blocks adenosine transport and inhibits phosphodiesterase), (3) dipyridamole plus EHNA, and (4) adenosine with or without EHNA. [3H]Thymidine incorporation and cell number were measured after 24 ...Continue Reading

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Citations

Jul 2, 2003·Cellular Signalling·Gunnar Schulte, Bertil B Fredholm
Jan 27, 2011·Journal of Cardiovascular Pharmacology·Rachel W S LiGeorge P H Leung
Jul 29, 2000·Canadian Journal of Physiology and Pharmacology·E S Werstiuk, R M Lee
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Sep 3, 2021·European Journal of Medical Genetics·Andressa Barreto GlaeserRafael Fabiano Machado Rosa

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