Smooth muscle cell differentiation in the processus vaginalis of children with hernia or hydrocele.

Hernia : the Journal of Hernias and Abdominal Wall Surgery
V K MouravasI Kostopoulos

Abstract

Incomplete obliteration of the processus vaginalis (PV) in children with inguinal hernia or hydrocele has recently been proposed to relate to smooth muscle cell (SMC) persistence. The aim of this study was to evaluate the diversity and differentiation of smooth muscle phenotypes in sacs associated with inguinal hernia and hydrocele through the expression of alpha-smooth muscle actin (SMA), h-caldesmon, desmin, and vimentin. Sacs associated with male hernia (n = 22), female hernia (n = 8), and hydrocele (n = 10) were immunohistochemically evaluated using monoclonal antibodies against SMA, h-caldesmon, desmin, and vimentin. Peritoneal samples (male, 4; female, 3) and obliterated PV (male, 3) obtained from age-matched patients served as controls. Expressions according to the groups were compared through chi-squared test, and P values less than 0.05 were considered to be statistically significant. Immunohistochemistry did not shown the presence of SMCs in control samples. The expression of SMA, desmin, and h-caldesmon did not differ among sacs obtained from patients with inguinal hernia and hydrocele. However, strong expression of vimentin in SMCs within sacs obtained from patients with hydrocele in comparison with sacs from male p...Continue Reading

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Citations

Jan 19, 2016·Molecular and Cellular Endocrinology·Yanchun Liang, Shuzhong Yao
Mar 4, 2015·Hernia : the Journal of Hernias and Abdominal Wall Surgery·V Mouravas, D Sfoungaris
Nov 29, 2014·Hernia : the Journal of Hernias and Abdominal Wall Surgery·Z P JiangS Chen
Jul 28, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Dimitrios Sfoungaris, Vassilios Mouravas
Oct 12, 2017·Frontiers in Surgery·Stina ÖbergJacob Rosenberg

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