Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity

Cellular Signalling
Agne FrismantieneTherese J Resink

Abstract

Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike many other mature cell types in the adult body, VSMC do not terminally differentiate but retain a remarkable plasticity. Fully differentiated medial VSMCs of mature vessels maintain quiescence and express a range of genes and proteins important for contraction/dilation, which allows them to control systemic and local pressure through the regulation of vascular tone. In response to vascular injury or alterations in local environmental cues, differentiated/contractile VSMCs are capable of switching to a dedifferentiated phenotype characterized by increased proliferation, migration and extracellular matrix synthesis in concert with decreased expression of contractile markers. Imbalanced VSMC plasticity results in maladaptive phenotype alterations that ultimately lead to progression of a variety of VSMC-driven vascular diseases. The nature, extent and consequences of dysregulated VSMC phenotype alterations are diverse, reflecting the numerous environmental cues (e.g. biochemical factors, extracellular matrix components, physical) that prompt VSMC phenotype switching. In spite of decades of efforts to understand cues and processes that normally con...Continue Reading

Citations

Aug 20, 2019·Journal of Cardiovascular Pharmacology·Simon Topp ChristensenKristian Agmund Haanes
Oct 19, 2019·Journal of Clinical Medicine·Stasė GasiulėGiedrius Vilkaitis
Jun 5, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takuro Numaga-TomitaMotohiro Nishida
Mar 27, 2020·Biomolecules·Samira Hosseini-Alghaderi, Martin Baron
Apr 18, 2020·American Journal of Hypertension·Takayuki MatsumotoTsuneo Kobayashi
Apr 29, 2020·Journal of Cellular Physiology·Xiaofeng ShiLei Li
Sep 5, 2020·Journal of Cellular and Molecular Medicine·Mengdie ChengHui Xin
Nov 9, 2018·Frontiers in Cardiovascular Medicine·Manna LiJian Xu
Nov 7, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Norifumi NishidaYoshihiro Fukumoto
Apr 7, 2020·Journal of Animal Science·Xu JiHonglin Jiang
Dec 27, 2019·World Journal of Stem Cells·Ge-Er TianYong-Can Huang
Aug 22, 2020·Journal of Lipid and Atherosclerosis·Motohiro NishidaAkiyuki Nishimura
Nov 20, 2019·International Journal of Molecular Sciences·Armand JaminonLeon Schurgers
Jan 9, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Vidhi DhagiaSachin A Gupte
Jan 9, 2021·Clinical Science·Jakob VoelklCarsten A Wagner
Dec 5, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gregory Livshits, Alexander Kalinkovich
Oct 13, 2020·Circulation Research·Redouane AherrahrouMete Civelek
Jan 31, 2021·Genes·Tyler J CreamerElena Gallo MacFarlane
Nov 25, 2020·Molecular Therapy. Nucleic Acids·Yeong-Hwan LimYoung-Kook Kim
Mar 3, 2021·Acta Biomaterialia·Suzette T LustEileen Gentleman
Mar 27, 2021·Frontiers in Pharmacology·Yunyun ZhaoZhongqun Wang
Mar 25, 2021·The Journal of Pharmacology and Experimental Therapeutics·Atsushi KitagawaSachin A Gupte
Apr 18, 2021·Molecular Nutrition & Food Research·Jun TangDuo Li
May 11, 2021·Frontiers in Cardiovascular Medicine·Wenhong JiangXiao Qin
May 25, 2021·Circulation Research·Tiit ÖrdMinna U Kaikkonen
May 29, 2021·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Yunsun SongDae Chul Suh
Jun 15, 2021·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Jennifer Ayers-RinglerRamanathan Kadirvel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.