Smooth muscle cell migration into intima and adventitia during development of transplant vasculopathy

Transplantation
L M AkyürekB Fellström

Abstract

Smooth muscle cell (SMC) migration from the medial layer into the intima is a characteristic feature of transplant vasculopathy and is thought to be regulated by locally produced cytokines. We studied the expression of smooth muscle alpha-actin, PDGF B-ligand and, PDGF alpha- and beta-receptors in rat aortic allografts with transplant vasculopathy using immunohistochemistry. At two weeks, an intense expression of PDGF B-ligand and, PDGF alpha- and beta-receptors was found in the neointima and adventitia. Medial SMC expression decreased with time in parallel with accumulation of smooth muscle alpha-actin in the neointima and adventitia. PDGF expression persisted in the adventitia. Prolonged ischemic storage time resulted in an increase in the number of alpha-actin-positive SMCs in the intima of syngeneic grafts. These data indicate that SMCs migrate into both the intima and adventitia. This migration may be induced, at least in part, by PDGF produced by graft invading monocyte-derived macrophages.

Citations

Dec 31, 2002·Journal of Molecular and Cellular Cardiology·Rüdiger BlindtAnja-Katrin Bosserhoff
Dec 29, 1998·Transplantation Proceedings·A Szabo, U Heemann
Aug 10, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·C G Orosz
Jun 27, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S Kitagawa-SakakidaR Shirakura
Nov 23, 2013·Journal of Thrombosis and Thrombolysis·Kristina L Modjeski, Craig N Morrell
Jul 5, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Paul JohnsonTim Lee
Jul 13, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Simone A JoostenLeendert C Paul
May 28, 2008·Transplant Immunology·Maria CurrieTimothy D G Lee
Feb 21, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Emile AndriambelosonMarc Bigaud
Mar 30, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Aya Miyagawa-HayashinoToshiaki Manabe
Sep 12, 2000·The American Journal of Pathology·J F LégaréG Hirsch
Jul 17, 1998·The American Journal of Pathology·J ChenL C Paul

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.