Smooth muscle contractility in prostatic hyperplasia: role of cyclic adenosine monophosphate

The Prostate
P DrescherP O Madsen

Abstract

The role of cyclic 3'-5' adenosine monophosphate (cAMP) on alpha 1-adrenoceptor (alpha 1-receptor) induced smooth muscle contractions in symptomatic benign prostatic hyperplasia (BPH) was investigated. Application of the selective alpha 1-receptor agonist phenylephrine (PE) induced fully reversible contractions in a dose-dependent fashion. Phosphodiesterase (PDE) inhibitors blocking the degradation of cAMP suppressed the PE induced contractions as follows: theophylline (1 mM), 91.1 +/- 1.4%; papaverine (0.5 mM), 822.8 +/- 3.2%; milrinone (0.5 mM), 68.2 +/- 0.6%. Forskolin (50 microM), which elevates cAMP through direct activation of adenylatecyclase (AC), inhibited the PE induced contractions by 82.4 +/- 3.6%. To further increase the intracellular cAMP concentration ([cAMP]i), the membrane permeable cAMP analogue N6-2'-O-dibutyryladenosine derivative (dBcAMP; 1 mM) was applied and reduced the PE evoked contractions by 69.8 +/- 2.3%. We conclude that elevation of [cAMP]i is an important step in inducing smooth muscle relaxation.

References

Jan 1, 1991·Scandinavian Journal of Urology and Nephrology·M L RuutuM J Mattila
Jul 24, 1991·JAMA : the Journal of the American Medical Association·P Cotton
Jan 1, 1990·The Prostate·J BruynseelsG Vanden Bussche
Jan 1, 1990·Urological Research·L Hertle, H Nawrath
Jan 1, 1989·Annual Review of Physiology·K E Kamm, J T Stull
Nov 1, 1989·Trends in Pharmacological Sciences·A LaurenzaK B Seamon
Jan 1, 1994·Urological Research·P DrescherP O Madsen

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Citations

Jul 5, 2007·Der Urologe. Ausg. A·P SandnerE Ulbrich
Jul 13, 2007·International Journal of Impotence Research·P SandnerE Bischoff
Sep 22, 2005·Clinical and Experimental Pharmacology & Physiology·John M Haynes, Sabatino Ventura
Oct 22, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·Y KurokawaY Nakaya
Dec 28, 2007·European Urology·Lambertus P W WitteMartin C Michel
Jul 29, 2008·European Journal of Pharmacology·Katherine T GraySab Ventura
Feb 9, 2006·British Journal of Pharmacology·Martin C Michel, Wim Vrydag
Mar 18, 2011·British Journal of Pharmacology·S VenturaB Exintaris
Jun 29, 2018·Toxins·Jia-Fong Jhang, Hann-Chorng Kuo

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