Smooth muscle fraction of the round ligament in women with pelvic organ prolapse: a computer-based morphometric analysis

International Urogynecology Journal and Pelvic Floor Dysfunction
Ozlem OzdegirmenciBulent Celasun

Abstract

Our objective was to compare the collagen and muscle content of the round ligament of uteri in women with pelvic organ prolapse. We evaluated the tissue samples obtained from the round ligaments of 22 patients with uterine prolapse who underwent vaginal hysterectomy (group A, study) and from 26 patients with no pelvic relaxation in whom total abdominal hysterectomy was performed for benign reasons (group B, controls). Morphometric analysis was performed on histologic cross-sections of the round ligament. Sections from each sample were stained with hematoxylin and eosin and Masson's trichrome methods. A computer system was used for morphometric measurements. We used independent samples t-test or Mann-Whitney U test to investigate the difference between the two groups. It was found that the smooth muscle fraction of the round ligament in women with uterine prolapse was significantly decreased compared with that of healthy control subjects and concluded that decreased smooth muscle content may be an important pathogenetic factor in uterine prolapse.

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Citations

Dec 13, 2005·International Urogynecology Journal and Pelvic Floor Dysfunction·Boris GabrielAxel zur Hausen
Dec 6, 2008·Molecular Human Reproduction·S S BrizzolaraJ Urschitz
Jun 2, 2006·International Urogynecology Journal and Pelvic Floor Dysfunction·Harold P Drutz, May Alarab
Jul 8, 2009·International Urogynecology Journal and Pelvic Floor Dysfunction·Peter TakacsCarlos A Medina
Aug 5, 2009·International Urogynecology Journal and Pelvic Floor Dysfunction·Yakir SegevYoram Abramov
Jan 21, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Peter von Theobald
Dec 9, 2009·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·E RagniP Costa
Mar 17, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Steven D AbramowitchPamela A Moalli
Nov 4, 2010·Neurourology and Urodynamics·Petek Balkanli KaplanBurcu Tokuc
Sep 23, 2009·Neurourology and Urodynamics·Elizabeth MosierPhilippe Zimmern
Aug 25, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·Z JallahP Moalli
Apr 24, 2010·American Journal of Obstetrics and Gynecology·Peter TakacsCarlos A Medina
Dec 19, 2008·Reproductive Sciences·Peter TakacsCarlos A Medina
Apr 6, 2018·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Mehmet ÇağlayanKemal Nas
Jul 25, 2009·Menopause : the Journal of the North American Menopause Society·Andrea TinelliCarlo Cavallotti
Jul 14, 2005·Clinical Obstetrics and Gynecology·Joseph I SchafferMuriel K Boreham
Sep 27, 2018·Experimental and Therapeutic Medicine·Gui FangHua Shi

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