Smooth Muscle Hypoxia-Inducible Factor 1α Links Intravascular Pressure and Atherosclerosis

Arteriosclerosis, Thrombosis, and Vascular Biology
Dinggang LiuFrank J Giordano

Abstract

We hypothesized that the hypoxia-inducible factor (HIF) 1α in vascular smooth muscle contributes to the development of atherosclerosis, and links intravascular pressure to this process. Transverse aortic constriction was used to create high-pressure vascular segments in control, apolipoprotein E (ApoE)(-/-), smooth muscle-HIF1α(-/-), and ApoE(-/-)×smooth muscle-HIF1α(-/-) double-knockout mice. Transverse aortic constriction selectively induced atherosclerosis in high-pressure vascular segments in young ApoE(-/-) mice on normal chow, including coronary plaques within 1 month. Concomitant deletion of HIF1α from smooth muscle significantly reduced vascular inflammation, and attenuated atherosclerosis. HIF1α in vascular smooth muscle plays an important role in the pathogenesis of atherosclerosis, and may provide a mechanistic link between blood pressure, vascular inflammation, and lipid deposition.

References

May 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yan HuangFrank J Giordano
Dec 22, 2006·Genes & Development·Amit Maity, Constantinos Koumenis
Mar 25, 2009·The Journal of Pathology·Judith C Sluimer, Mat J Daemen
Jul 14, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tina GimmChristina Warnecke

❮ Previous
Next ❯

Citations

Sep 9, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Shuang FengPaul C Evans
Jul 23, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Annemarie AarupLars B Nielsen
Feb 10, 2019·Clinical Science·Fernando Pedro de Souza-NetoRafaela Fernandes da Silva
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Pierre-Yves Jean-CharlesNeil J Freedman
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Hong S LuAlan Daugherty
Feb 5, 2021·Journal of the American College of Cardiology·Rozh H Al-MashhadiJacob F Bentzon
Oct 6, 2020·JACC. Basic to Translational Science·Milton Packer
Jul 13, 2021·Cardiology Clinics·Francesco LocatelliLuca De Nicola

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.