Abstract
We hypothesized that the hypoxia-inducible factor (HIF) 1α in vascular smooth muscle contributes to the development of atherosclerosis, and links intravascular pressure to this process. Transverse aortic constriction was used to create high-pressure vascular segments in control, apolipoprotein E (ApoE)(-/-), smooth muscle-HIF1α(-/-), and ApoE(-/-)×smooth muscle-HIF1α(-/-) double-knockout mice. Transverse aortic constriction selectively induced atherosclerosis in high-pressure vascular segments in young ApoE(-/-) mice on normal chow, including coronary plaques within 1 month. Concomitant deletion of HIF1α from smooth muscle significantly reduced vascular inflammation, and attenuated atherosclerosis. HIF1α in vascular smooth muscle plays an important role in the pathogenesis of atherosclerosis, and may provide a mechanistic link between blood pressure, vascular inflammation, and lipid deposition.
References
Apr 1, 1989·Atherosclerosis·T ZemplenyiM A Cole
May 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yan HuangFrank J Giordano
Jun 16, 2004·Circulation·Jie-Hong PanGuo-Ping Shi
Dec 22, 2006·Genes & Development·Amit Maity, Constantinos Koumenis
Feb 21, 2008·Molecular and Cellular Biology·Li LeiFrank J Giordano
Mar 25, 2009·The Journal of Pathology·Judith C Sluimer, Mat J Daemen
Jul 14, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tina GimmChristina Warnecke
Citations
Feb 19, 2017·Redox Biology·Fragiska SigalaIoanna Andreadou
Sep 9, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Shuang FengPaul C Evans
Jul 23, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Annemarie AarupLars B Nielsen
Feb 10, 2019·Clinical Science·Fernando Pedro de Souza-NetoRafaela Fernandes da Silva
Mar 10, 2019·Bioscience Reports·Qinshuo ZhaoJiangTao Yan
Sep 24, 2019·Molecular Medicine Reports·Qini ZhaoLibo Wang
May 3, 2019·JCI Insight·Alice MarinoAnnarita Di Lorenzo
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Pierre-Yves Jean-CharlesNeil J Freedman
Jan 17, 2020·Cells·Matilde AliqueRafael Ramírez
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Hong S LuAlan Daugherty
Feb 5, 2021·Journal of the American College of Cardiology·Rozh H Al-MashhadiJacob F Bentzon
Oct 6, 2020·JACC. Basic to Translational Science·Milton Packer
Jul 13, 2021·Cardiology Clinics·Francesco LocatelliLuca De Nicola