PMID: 7518197Apr 1, 1994Paper

Smooth-muscle proliferation in dermatofibromas

The American Journal of Dermatopathology
P E LeBoit, R J Barr

Abstract

Although a variety of epithelial changes have been associated with dermatofibromas, mesenchymal proliferations induced by dermatofibromas appear to be rare. We report three dermatofibromas that were associated with proliferation of smooth muscle within the adjacent dermis. The lesions ranged from a large, densely cellular dermatofibroma with "monster cells" to a sparsely cellular, fibrous lesion. In all three cases, the smooth muscle could be discerned in hematoxylin- and -eosin-stained sections, because its presence caused an interruption in the pattern of reticular dermal collagen bundles with blunt-ended vesicular nuclei. Well-formed fascicles were apparent in immunoperoxidase-stained sections using antisera to muscle-specific actin (HHF-35) and desmin. The smooth muscle failed to stain with either antisera to S-100 protein or Leu-7, precluding determination of whether it immunophenotypically resembled vascular or pilar smooth muscle. We believe that the smooth-muscle proliferation in our cases was induced by the spindled cells of dermatofibroma, just as epithelial changes in association with dermatofibroma are. We further believe that it is most likely of vascular derivation, based on a previous report of angioleiomyoma ari...Continue Reading

Citations

Apr 1, 1997·The American Journal of Dermatopathology·B W ZelgerK Rappersberger
May 20, 1998·The American Journal of Surgical Pathology·T T KuoH L Chan
May 9, 2001·The American Journal of Surgical Pathology·B G Zelger, B Zelger
Nov 28, 2013·Actas dermo-sifiliográficas·J R EstelaV Alegre
Dec 18, 2013·Journal of Cutaneous Pathology·Timothy H McCalmont
May 1, 1995·The Journal of Dermatology·L Requena, M Reichel
Dec 29, 2013·Case Reports in Otolaryngology·Turgut KarlidagBengu Cobanoglu
Aug 26, 2016·Indian Dermatology Online Journal·Amira ElbendaryShyam B Verma
Oct 21, 2004·International Journal of Surgical Pathology·Bernhard ZelgerWalter H C Burgdorf
Aug 1, 1995·Journal of Cutaneous Pathology·V G PrietoC R Shea
Sep 25, 2009·Journal of Cutaneous Pathology·Daniel González-VilasJaime Toribio
Jan 9, 2010·Histopathology·Bostjan Luzar, Eduardo Calonje
Dec 1, 1996·Journal of Cutaneous Pathology·J F Val-Bernal, C Mira
Jan 5, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·M HisaokaH Hashimoto
Sep 26, 2002·Archives of Pathology & Laboratory Medicine·Andrea K Bruecks, Martin J Trotter

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