Jul 1, 1977

Smooth muscle sensitization induced by colchicine: is it an in vitro property of antitubulin agents?

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J P FamaeyJ Reuse


Colchicine 0.1 microgram/ml induces a reversible increase of guinea-pig isolated ileum contractions (50 to 60% of maximal contractions) to acetylcholine, nicotine and PGE2. At 1 microgram/ml, it induces an irreversible increase of similar contractions to acetylcholine and 5-hydroxytryptamine. Low concentrations of indomethacin are able to reduce or even to abolish this increase. This smooth muscle sensitization could be related to the ability of colchicine to stimulate prostaglandin biosynthesis. Vinblastine has been described to induce a similar in vitro sensitization of guinea-pig isolated ileum. This effect might be also a non-specific property of antitubulin agents. The relationships between such an in vitro sensitization and the clinical effects of colchicine, including diarrhea, remain unclear.

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Mentioned in this Paper

Smooth Muscle
Tubulin Promoters
Drug Interactions
Colchicine, (R)-Isomer
In Vitro [Publication Type]

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