PMID: 3756265Oct 1, 1986Paper

Smooth pursuit eye movement disorder and its psychobiologic correlates in unmedicated schizophrenics

Biological Psychiatry
L J SieverD L Murphy

Abstract

The accuracy of smooth pursuit eye movements (SPEMs) was evaluated electrooculographically in 14 medication-free schizophrenics. Concentrations of monoamine metabolites and gamma-amino-butyric acid (GABA) were measured in their cerebrospinal fluid (CSF). Ventricular-brain ratios (VBR) were determined by computed axial tomography (CT scan). Premorbid adjustment was evaluated by the Phillips Scale. The SPEMs of eight of the patients were reevaluated after 2 weeks of treatment with either prazosin or pimozide. No consistent significant correlations were found between SPEM accuracy and CSF metabolite concentrations, VBR, or premorbid adjustment. SPEM accuracy was not correlated with number of days off medication and was significantly correlated when measured before and during medication.

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Citations

Apr 26, 2008·European Archives of Psychiatry and Clinical Neuroscience·H Magnus HaraldssonHannes Petursson
Nov 15, 1992·Biological Psychiatry·D CampionD Levillain
Jul 15, 1995·Biological Psychiatry·P Roy-ByrneD S Cowley
Apr 1, 1989·Psychiatry Research·M M ReaA Frances
Feb 27, 2001·Psychiatry Research·K H LeeE Gordon
Mar 10, 2000·Psychiatry Research·B KaroumiT d'Amato
Dec 29, 2000·The Australian and New Zealand Journal of Psychiatry·K H Lee, L M Williams
Aug 1, 1995·Acta Psychiatrica Scandinavica·R W Gråwe, S Levander
Jul 8, 1999·The International Journal of Neuroscience·M P Kelley, P Bakan

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