Smoothelin immunohistochemistry is a useful adjunct for assessing muscularis propria invasion in bladder carcinoma

Histopathology
Ian M BovioRobert W Allan

Abstract

To prospectively evaluate the utility of smoothelin immunohistochemical expression for the evaluation of muscularis propria (MP) in diagnostic transurethral resection of bladder tumour (TURBT) specimens and cystectomies. Smoothelin immunohistochemistry was performed on a total of 26 TURBT and cystectomy specimens. All but two cases (24/26) demonstrated strong (3+) or moderate (2+) immunoreactivity of the MP with smoothelin. Muscularis mucosae (MM) never displayed strong (3+) reactivity, and in only one case did the MM have moderate (2+) reactivity; in this case the MP had strong (3+) reactivity. MM intensity mirrored the intensity of reactivity of blood vessels in all cases (26/26). Using moderate or strong immunoreactivity as a cut-off, smoothelin had a sensitivity of 92% for detecting MP and a specificity of 97% for distinguishing between MP and MM. In all unequivocal MP-invasive and lamina proporia-invasive cases by haematoxylin and eosin (H&E), smoothelin immunohistochemistry confirmed the original light microscopic diagnosis. In four cases in which there was equivocal MP involvement by H&E, smoothelin helped establish MP invasion. Smoothelin immunohistochemistry has diagnostic utility in the evaluation of MP invasion in ur...Continue Reading

References

Jul 1, 1996·The Journal of Cell Biology·F T van der LoopG J van Eys
Feb 19, 1999·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·J KrämerH Leonhardt
Aug 23, 2000·The Journal of Urology·F Millán-RodríguezJ Vicente-Rodríguez
Feb 14, 2006·The Journal of Urology·C MaakeH John
Mar 29, 2006·BJU International·Hartwig E SchwaiboldRudolf Hartung
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

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Citations

Oct 16, 2012·Seminars in Diagnostic Pathology·Adeboye O Osunkoya, David J Grignon
Jun 29, 2011·Histopathology·Jose Aneiros-FernandezOvidiu Preda
Jun 14, 2017·Archives of Pathology & Laboratory Medicine·Xiuli XiaoChin-Lee Wu
Apr 17, 2020·Virchows Archiv : an International Journal of Pathology·Maria Rosaria RaspolliniAntonio Lopez-Beltran

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