Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy.

The Journal of Biological Chemistry
Beata LontayTimothy A J Haystead

Abstract

Pregnancy coordinately alters the contractile properties of both vascular and uterine smooth muscles reducing systemic blood pressure and maintaining uterine relaxation. The precise molecular mechanisms underlying these pregnancy-induced adaptations have yet to be fully defined but are likely to involve changes in the expression of proteins regulating myosin phosphorylation. Here we show that smoothelin like protein 1 (SMTNL1) is a key factor governing sexual development and pregnancy induced adaptations in smooth and striated muscle. A primary target gene of SMTNL1 in these muscles is myosin phosphatase-targeting subunit 1 (MYPT1). Deletion of SMTNL1 increases expression of MYPT1 30-40-fold in neonates and during development expression of both SMTNL1 and MYPT1 increases over 20-fold. Pregnancy also regulates SMTNL1 and MYPT1 expression, and deletion SMTNL1 greatly exaggerates expression of MYPT1 in vascular smooth muscle, producing a profound reduction in force development in response to phenylephrine as well as sensitizing the muscle to acetylcholine. We also show that MYPT1 is expressed in Type2a muscle fibers in mice and humans and its expression is regulated during pregnancy, suggesting unrecognized roles in mediating skel...Continue Reading

References

May 1, 1973·Biology of Reproduction·A K ChamplinA H Gates
Jul 1, 1995·Physiological Reviews·G K Owens
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·N L WeigelA Poletti
Apr 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·D P McDonnellM E Goldman
Mar 10, 2000·Seminars in Perinatology·K L ThornburgM J Morton
Mar 11, 2000·American Journal of Physiology. Cell Physiology·W P DirksenS A Fisher
Aug 26, 2000·Progress in Biophysics and Molecular Biology·R Bottinelli, C Reggiani
Jan 3, 2001·Journal of Applied Physiology·A J Halayko, J Solway
May 9, 2001·Biochimica Et Biophysica Acta·H MachidaT Nakano
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Sukrutha VeerareddySandra T Davidge
Feb 28, 2003·Reviews of Physiology, Biochemistry and Pharmacology·M Flück, H Hoppeler
Feb 12, 2004·Journal of Muscle Research and Cell Motility·Yue WuDavid J Hartshorne
Jul 2, 2004·American Journal of Physiology. Cell Physiology·Takayuki AkimotoZhen Yan
Jul 23, 2004·Physiological Reviews·Gary K OwensBrian R Wamhoff
Oct 7, 2004·Journal of Muscle Research and Cell Motility·Carlo Reggiani, Geertruuy Te Kronnie
Feb 16, 2005·Annual Review of Physiology·Dean P Edwards
Dec 13, 2005·The Journal of Physiology·Giuseppe D'AntonaRoberto Bottinelli
Jan 10, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Daliao XiaoLubo Zhang
Jan 25, 2006·Cellular Signalling·Ryuji OkamotoMasaaki Ito
Feb 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Daliao XiaoLubo Zhang
Dec 15, 1941·Proceedings of the National Academy of Sciences of the United States of America·H GrünebergG D Snell
Jul 17, 2007·Experimental Physiology·Stephen D R Harridge
Sep 29, 2007·Circulation Research·Avril V Somlyo
Dec 25, 2007·Biochemical and Biophysical Research Communications·Fumio Matsumura, David J Hartshorne
Feb 14, 2008·Advances in Experimental Medicine and Biology·Hans HoppelerMartin Flück
Mar 4, 2008·The Journal of Biological Chemistry·Anne A WooldridgeTimothy A J Haystead
Mar 28, 2008·Journal of Cellular and Molecular Medicine·X WuM J Taggart
May 28, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Renáta MinoricsGeorge Falkay
Sep 12, 2009·Experimental Cell Research·Erin TwomeyMarianna Sikorska

❮ Previous
Next ❯

Citations

Jul 21, 2011·The Journal of Biological Chemistry·Khaldon BodoorTimothy A Haystead
Mar 1, 2011·BMC Molecular Biology·Annegret Ulke-LeméeJustin A MacDonald
Apr 30, 2015·Journal of Cellular Biochemistry·Annegret Ulke-LeméeJustin A MacDonald
Nov 26, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Sara R Turner, Justin A MacDonald
Sep 4, 2015·Molecular Biology and Evolution·Camilla M WhittingtonAnthony B Wilson
Jun 7, 2014·Biochimica Et Biophysica Acta·Annegret Ulke-LeméeJustin A MacDonald
Jan 18, 2013·American Journal of Physiology. Cell Physiology·Trent ButlerEng-Cheng Chan
Jun 2, 2020·Frontiers in Cell and Developmental Biology·Lei-Miao YinChang-Duk Jun
Jan 19, 2021·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Ai KonoKei Kawana
Dec 5, 2020·Current Biology : CB·Mariam HachimiFernando Martin-Belmonte
Nov 24, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Cláudia FerreiraRita Nogueira-Ferreira

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.