PMID: 40550Jul 15, 1979

sn-Glycero(3)phosphoinositol glycerophosphohydrolase. A new phosphodiesterase in rat tissues

The Biochemical Journal
R M DawsonRobin F Irvine

Abstract

1. A phosphodiesterase that cleaves glycerophosphoinositol into glycerophosphate and inositol has been detected in rat tissues. 2. The enzyme requires Mg2+ (Mn2+) and has a pH optimum of 7.7. 3. The richest sources of the enzyme are kidney and intestinal mucosa. In pancreas subcellular fractions it occurs largely in the microsomal fraction. 4. The enzyme is inhibited by excess substrate and by the reaction product glycerophosphate. 5. Temperature-stability studies and other observations distinguish the enzyme from other membrane-bound phosphodiesterases active at an alkaline pH e.g. glycerophosphoinositol inositophosphohydrolase, glycerophosphocholine diesterase, inositol cyclic phosphate phosphodiesterase and phosphodiesterase I.

References

Apr 30, 2005·The Journal of Physiology·Robin F Irvine
Feb 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Bin ZhengMarilyn G Farquhar
Sep 6, 2005·The Journal of Biological Chemistry·Edward FisherJana Patton-Vogt

Related Concepts

Cations, Divalent
Phosphodiesterase Inhibitors
Phosphatidylinositols
Phosphoric diester hydrolase
Benign Tumor of Pancreas
Phosphodiesterase I
glycerylphosphoinositol
Glycerylphosphorylcholine
Inositol cyclic phosphate
Subcellular Fractions

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