PMID: 8586635May 1, 1995Paper

sn-glycerol-1-phosphate dehydrogenase in Methanobacterium thermoautotrophicum: key enzyme in biosynthesis of the enantiomeric glycerophosphate backbone of ether phospholipids of archaebacteria

Journal of Biochemistry
M Nishihara, Yosuke Koga

Abstract

One of the most characteristic features of archaebacterial ether phospholipids is the enantiomeric configuration of their glycerophosphate backbone (sn-glycerol-1-phosphate), that is the mirror image of the structure of the eubacterial or eukaryotic counterpart. The enzyme that forms glycerophosphate of this configuration was found for the first time in a cell-free extract of the methanogen, Methanobacterium thermoautotrophicum, and was identified as sn-glycerol-1-phosphate:NAD+ oxidoreductase (sn-glycerol-1-phosphate dehydrogenase) after partial purification. Because sn-glycerol-1-phosphate has been found to be a precursor of ether lipids of this organism, sn-glycerol-1-phosphate dehydrogenase is a key enzyme in the biosynthesis of the enantiomeric ether lipids of methanogens.

Citations

Apr 7, 2004·Molecular Microbiology·Yan BoucherW Ford Doolittle
Nov 13, 2012·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·David Aparicio AlarconPeter C Loewen
Jul 16, 2015·The Journal of Biological Chemistry·Vincenzo CarboneRon S Ronimus
Mar 10, 2007·Microbiology and Molecular Biology Reviews : MMBR·Yosuke Koga, Hiroyuki Morii
Apr 6, 2006·Environmental Microbiology·Johan W H WeijersJaap S Sinninghe Damsté
Jul 5, 2005·Analytical Biochemistry·Yosuke Koga, Hiroyuki Morii
Nov 3, 2010·Research in Microbiology·Rie MatsumiJohn van der Oost

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