SN2-Palmitate Reduces Fatty Acid Excretion in Chinese Formula-fed Infants

Journal of Pediatric Gastroenterology and Nutrition
Fabiana Bar-YosephChungdi Xu

Abstract

Palmitic acid (PA) comprises 17% to 25% of human milk fatty acids, of which 70% to 75% are esterified to the SN2 position of the triglyceride (SN2-palmitate). In vegetable oils, which are commonly used in infant formulas, palmitate is primarily esterified to other positions, resulting in reduced calcium and fat absorption and hard stools. The aim of this study was to elucidate the effects of SN2-palmitate on nutrient excretion. In total, 171 Chinese infants were included (within 14 days of birth) in this multicenter study. Formula-fed infants were randomly assigned to receive either SN2-palmitate formula (INFAT, n = 57) or control formula (n = 57). The formulas (Biostime, China) differed only in their SN2 PA proportions. Stool was collected at 6 postnatal weeks. The stool dry weight and fat content of the SN2-palmitate group were lower compared with the control group (dry weight 4.25 g vs 7.28 g, P < 0.05; fat 0.8 g vs 1.2 g, P < 0.05). The lipid component was also significantly lower for the SN2-palmitate group (0.79 g vs 1.19 g, P < 0.05). PA, representing ∼50% of the saponified fatty acids, was significantly lower in the SN2-palmitate group compared with the control group (0.3 g vs 0.7 g, P < 0.01). Breast-fed infants had a ...Continue Reading

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Citations

Nov 14, 2017·Journal of Oleo Science·Toshiharu NagaiNaohiro Gotoh
Sep 6, 2019·Nutrients·Candice Quin, Deanna L Gibson
Feb 23, 2019·Journal of Pediatric Gastroenterology and Nutrition·Jiri BronskyUNKNOWN ESPGHAN Committee on Nutrition
Sep 3, 2020·Critical Reviews in Food Science and Nutrition·Rodolfo Lázaro Soares ViriatoMirna Lúcia Gigante
Aug 7, 2019·International Journal of Food Sciences and Nutrition·Jing WangChun Li
Jan 26, 2021·Nutrition Reviews·Natalia Wawrzyniak, Joanna Suliburska
Feb 24, 2021·The Cochrane Database of Systematic Reviews·Laura PerrettaHeather L Brumberg
Jun 29, 2021·MicrobiologyOpen·Lu WangHermie J M Harmsen
Apr 21, 2020·Journal of Agricultural and Food Chemistry·Tinglan YuanHua Xiong

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