Snail homolog 1 is involved in epithelial-mesenchymal transition-like processes in human glioblastoma cells

Oncology Letters
Caspar D KühnölChristof Kramm

Abstract

Despite advancements in neurosurgery, chemotherapy and radiation therapy, the outcome of patients with glioblastoma remains poor. The migration of tumor cells from the primary tumor site with subsequent invasion of these cells into the surrounding normal brain tissue is frequently responsible for relapse and treatment failure. The present study hypothesized that snail homolog 1 (SNAI1), a factor critically involved in the epithelial-mesenchymal transition (EMT) of human carcinoma cells, may also contribute to an invasive EMT-like phenotype of glioblastoma cells. The majority of glioblastoma cell lines investigated in the present study expressed SNAI1 at basal levels. The present study overexpressed SNAI1 in glioblastoma cell lines by lentiviral transfer of human SNAI1 complementary DNA. In addition, the inhibition of SNAI1 expression was achieved by lentiviral transfer of a short hairpin RNA specific for SNAI1. SNAI1 overexpression increased proliferation of one of the cell lines, U251MG, but exhibited only a weak effect on the migration and invasion of glioblastoma cells. However, downregulation of SNAI1 significantly decreased the invasive capacity of all investigated cell lines. In parallel, regained expression of E-cadherin...Continue Reading

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Nov 3, 2017·Nature·Robert H Miller
Nov 23, 2017·Cellular and Molecular Life Sciences : CMLS·Michaël H MeelEsther Hulleman
Mar 18, 2020·International Journal of Molecular Sciences·Arabel Vollmann-ZwerenzPeter Hau

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