Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids

Toxicon : Official Journal of the International Society on Toxinology
Julián FernándezBruno Lomonte

Abstract

Protein composition, toxicity, and neutralization of the venoms of Micrurus alleni and Micrurus mosquitensis, two sympatric monadal coral snakes found in humid environments of the Caribbean region of Costa Rica, were studied. Proteomic profiling revealed that these venoms display highly divergent compositions: the former dominated by three-finger toxins (3FTx) and the latter by phospholipases A2 (PLA2). Protein family abundances correlated with enzymatic and toxic characteristics of the venoms. Selective inhibition experiments showed that PLA2s play only a marginal role in the lethal effect of M. alleni venom, but have a major role in M. mosquitensis venom. Proteomic data gathered from other Micrurus species evidenced that the two divergent venom phenotypes are recurrent, and may constitute a general trend across New World elapids. Further, M. mosquitensis, but not M. alleni, venom contains PLA2-like/Kunitz-type inhibitor complex(es) that resemble the ASIC1a/2-activating MitTx heterodimeric toxin isolated from Micrurus tener venom. The evolutionary origin and adaptive relevance of the puzzling phenotypic variability of Micrurus venoms remain to be understood. An antivenom against the PLA2-predominant Micrurus nigrocinctus venom...Continue Reading

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Citations

Feb 16, 2016·Journal of Proteomics·Line P LauridsenJosé María Gutiérrez
Nov 7, 2015·Toxicon : Official Journal of the International Society on Toxinology·Juan J Calvete, Bruno Lomonte
Apr 6, 2016·Toxicon : Official Journal of the International Society on Toxinology·Gabriela D TanakaDenise V Tambourgi
Jul 16, 2016·Journal of Proteomics·Esther Lai Har TangNget Hong Tan
Oct 30, 2016·Toxicon : Official Journal of the International Society on Toxinology·Bruno LomonteJuan J Calvete
Sep 18, 2016·Integrative and Comparative Biology·Stephen P Mackessy, Anthony J Saviola
Jul 5, 2016·Journal of Proteomics·Carolina A NicolauRichard H Valente
Sep 21, 2017·Toxins·Theo Tasoulis, Geoffrey K Isbister
Feb 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yiding WangChunhong Huang
May 3, 2018·Molecular & Cellular Proteomics : MCP·Débora Andrade-SilvaVernon Reinhold
Aug 5, 2018·Rapid Communications in Mass Spectrometry : RCM·Parviz GhezellouBernhard Spengler
Mar 12, 2019·PLoS Neglected Tropical Diseases·María Carlina Castillo-BeltránFrancisco Javier Ruiz-Gómez
Feb 22, 2017·The Biochemical Journal·Juan J Calvete
Jan 25, 2020·PloS One·Justin L RheubertRobert A Charvat
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Sep 16, 2020·Biologicals : Journal of the International Association of Biological Standardization·Paola Rey-Suárez, Bruno Lomonte
Dec 15, 2020·Wilderness & Environmental Medicine·Nicholas V TitelbaumJames L Wilson
Aug 7, 2020·Toxicon : Official Journal of the International Society on Toxinology·Rafael S FlorianoEdward G Rowan
Mar 7, 2018·Toxicon : Official Journal of the International Society on Toxinology·José María Gutiérrez
Jul 26, 2021·Toxicon : Official Journal of the International Society on Toxinology·Adolfo Rafael de RoodtAlejandro Alagón
Apr 17, 2019·Toxicon : Official Journal of the International Society on Toxinology·Tiago H Moretto Del-ReiAna M Moura-da-Silva

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