Snake Venoms in Cancer Therapy: Past, Present and Future

Toxins
Li LiYao Lin

Abstract

Cancer is one of the leading causes of morbidity and mortality worldwide, and the discovery of new drugs for cancer therapy is one of the most important objectives for the pharmaceutical industry. Snake venoms are complex mixtures containing different peptides, proteins, enzymes, carbohydrates and other bioactive molecules, which are secreted by the snake in the predation or defending against threats. Understanding the snake venoms may turn the toxins into a valuable source of new lead compounds in drug discovery. Captopril, the first angiotensin-converting enzyme inhibitor approved in 1981 by FDA, was designed based on the structure of a peptide isolated from the snake venom. The earliest reports about snake venoms used in cancer treatments appeared in the 1930s. Since then, numerous studies on the activities, isolations, purifications and structure elucidations of the components from snake venoms were published. The comprehensive structural and functional investigations of snake venoms would contribute to the development of novel anti-cancer drugs. Our review will focus on the past, present and the future of the studies on snake venoms in cancer target therapy.

References

Jan 1, 1976·Methods in Enzymology·K Stocker, G H Barlow
Nov 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·R J GouldS Niewiarowski
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·C TakasakiT Kajiyashiki
Jun 9, 1983·Biochimica Et Biophysica Acta·C Ouyang, T F Huang
Apr 15, 1994·Cancer·J F KerrB V Harmon
Jan 15, 1993·Biochemical and Biophysical Research Communications·S ArakiH Hayashi
Jul 5, 1996·Biochemical and Biophysical Research Communications·S M Suhr, D S Kim
Jun 9, 1997·Biochemical and Biophysical Research Communications·S MasudaH Hayashi
Oct 6, 1999·Current Opinion in Structural Biology·K Drickamer
Jan 23, 2003·Protein Science : a Publication of the Protein Society·M Paz Moreno-MurcianoCezary Marcinkiewicz
Oct 1, 1951·Archives of Biochemistry and Biophysics·E B KEARNEY, T P SINGER
Oct 1, 1951·Archives of Biochemistry and Biophysics·E B KEARNEY, T P SINGER
Oct 1, 1951·Archives of Biochemistry and Biophysics·E B KEARNEY, T P SINGER
Nov 19, 2004·Nature·Charles Sawyers
Dec 8, 2004·Toxicon : Official Journal of the International Society on Toxinology·Tomohisa OgawaMotonori Ohno
May 14, 2005·CA: a Cancer Journal for Clinicians·Irene M GhobrialAlex A Adjei
Jan 1, 1936·Proceedings of the National Academy of Sciences of the United States of America·D I Macht
Nov 15, 2006·Cellular and Molecular Life Sciences : CMLS·D C I KohK Jeyaseelan
Apr 4, 2007·Toxicon : Official Journal of the International Society on Toxinology·Yao-Ping HanJuan Xu
Jul 11, 2007·Journal of Mass Spectrometry : JMS·Juan J CalveteLibia Sanz
Mar 20, 1936·Science·F Duran-Reynals
Jun 7, 2011·Toxicon : Official Journal of the International Society on Toxinology·D A HiguchiJ L Pesquero
Aug 3, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Mohamed K Al-SadoonGamal Badr
Sep 25, 2012·Toxicon : Official Journal of the International Society on Toxinology·Francis S Markland, Stephen Swenson
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Feb 9, 2016·Lancet·Gordon C JaysonAdrian L Harris
Jun 2, 2016·Applied Microbiology and Biotechnology·Yau Sang ChanWai Yee Chan
Jun 3, 2016·CA: a Cancer Journal for Clinicians·Kimberly D MillerAhmedin Jemal
Sep 15, 2017·Nature Reviews. Disease Primers·José María GutiérrezDavid A Warrell
Feb 8, 2018·Toxins·Suchaya SanhajariyaGeoffrey K Isbister

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Citations

Feb 6, 2019·Toxins·Syafiq Asnawi Zainal AbidinRakesh Naidu
Jun 16, 2019·Toxins·Hang Fai Kwok
Aug 7, 2019·Current Topics in Medicinal Chemistry·Leonel Montealegre-SánchezEliécer Jiménez-Charris
Mar 19, 2020·Animals : an Open Access Journal From MDPI·Aleksandra BocianJaroslav Legáth
May 15, 2020·Molecular Biology Reports·Alejandro Montoya-GómezEliécer Jiménez-Charris
May 20, 2020·Seminars in Cancer Biology·Félix A Urra, Ramiro Araya-Maturana
Jan 25, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Lorena PolloniVeridiana de Melo Rodrigues
Jul 3, 2021·Biomedicines·Assunta SaideChiara Lauritano
Mar 17, 2020·Toxicon : Official Journal of the International Society on Toxinology·Syeda U HashmiSyed A Ali
Nov 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mostafa I AbdelglilAly F Mohamed

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Methods Mentioned

BETA
xenografts
flow cytometry

Software Mentioned

GLOBOCAN

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