SNAP-25 in Major Psychiatric Disorders: A Review

Neuroscience
Katherine NajeraPeter M Thompson

Abstract

Synaptosomal Associated Protein-25 kilodaltons (SNAP-25) is an integral member of the SNARE complex. This complex is essential for calcium-triggered synaptic vesicular fusion and release of neurotransmitters into the synaptic cleft. In addition to neurotransmission, SNAP-25 is associated with insulin release, the regulation of intracellular calcium, and neuroplasticity. Because of SNAP-25's varied and crucial biological roles, the consequences of changes in this protein can be seen in both the central nervous system and the periphery. In this review, we will look at the published literature from human genetic, postmortem, and animal studies involving SNAP-25. The accumulated data indicate that SNAP-25 may be linked with some symptoms associated with a variety of psychiatric disorders. These disorders include bipolar disorder, schizophrenia, major depressive disorder, attention deficit hyperactivity disorder, autism, alcohol use disorder, and dementia. There are also data suggesting SNAP-25 may be involved with non-psychiatric seizures and metabolic disorders. We believe investigation of SNAP-25 is important for understanding both normal behavior and some aspects of the pathophysiology of behavior seen with psychiatric disorders...Continue Reading

Citations

Feb 13, 2020·Molecular Psychiatry·Aldo Córdova-PalomeraLars T Westlye
Jan 26, 2021·Psychiatric Genetics·Delfina JaniriGabriele Sani
Jun 3, 2021·International Journal of Environmental Research and Public Health·Yu-Chi HuangCheng-Sheng Chen
Jul 23, 2021·Journal of Translational Medicine·Simone AgostiniUNKNOWN SA. M. B. A. project

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