Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface.

Immunity
Lieselotte Vande Walle, Mohamed Lamkanfi

Abstract

Proteolytic maturation of the pore-forming protein gasdermin D (GSDMD) by inflammasome-activated caspase-1 is crucial for initiating pyroptosis, a lytic form of cell death. In this issue of Immunity, Lui et al. report the X-ray structure of the caspase-1-GSDMD complex, mapping the interaction interfaces that determine recognition and cleavage of GSDMD by inflammatory caspases.

References

Jan 5, 2000·Genes & Development·J Rodriguez, Y Lazebnik
Mar 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Dave BoucherJean-Bernard Denault
May 27, 2014·Cell·Mohamed Lamkanfi, Vishva M Dixit

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Citations

Jan 8, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jiasi WuXianli Meng

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