SncRNA (microRNA &snoRNA) opposite expression pattern found in multiple sclerosis relapse and remission is sex dependent

Scientific Reports
M Muñoz-CullaD Otaegui

Abstract

Multiple sclerosis (MS) is a common inflammatory and degenerative disease that causes neurological disability. It affects young adults and its prevalence is higher in women. The most common form is manifested as a series of acute episodes of neurological disability (relapses) followed by a recovery phase (remission). Recently, non-coding RNAs have emerged as new players in transcriptome regulation, and in turn, they could have a significant role in MS pathogenesis. In this context, our aim was to investigate the involvement of microRNAs and snoRNAs in the relapse-remission dynamics of MS in peripheral blood leucocytes, to shed light on the molecular and regulatory mechanisms that underlie this complex process. With this approach, we found that a subset of small non-coding RNAs (sncRNA) is altered in relapse and remission, revealing unexpected opposite changes that are sex dependent. Furthermore, we found that a relapse-related miRNA signature regulated general metabolism processes in leucocytes, and miRNA altered in remission are involved in the regulation of innate immunity. We observed that sncRNA dysregulation is different in relapse and remission leading to differences in transcriptome regulation, and that this process is s...Continue Reading

References

Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Feb 22, 2001·Science·J C VenterX Zhu
Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 18, 2005·Annual Review of Immunology·Mireia Sospedra, Roland Martin
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Feb 24, 2007·Nature Reviews. Molecular Cell Biology·A Gregory MateraMichael P Terns
Mar 10, 2007·Journal of the Neurological Sciences·Timothy Vollmer
Jan 15, 2008·Cell·Ana EulalioElisa Izaurralde
Jul 23, 2008·Nature Immunology·David BaltimoreKonstantin D Taganov
Mar 20, 2009·Human Molecular Genetics·Marc S Weinberg, Matthew J A Wood
Jul 21, 2009·PloS One·David OtaeguiAdolfo López de Munain
Aug 1, 2009·Trends in Immunology·Brandi J BakerEtty N Benveniste
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Leandro CastellanoJustin Stebbing
Oct 15, 2009·Cancer Research·Gérard MaillotStéphan Vagner
Jan 26, 2010·Nature Reviews. Immunology·Ryan M O'ConnellDavid Baltimore
Apr 1, 2010·Nature Reviews. Neuroscience·Xuekun Li, Peng Jin
Jul 14, 2010·Nature Reviews. Neurology·Jorge R Oksenberg, Sergio E Baranzini
Dec 15, 2010·Bioinformatics·Michael E SmootTrey Ideker
Apr 9, 2011·Journal of Neuroimmunology·Judith M Greer, Pamela A McCombe
Jun 24, 2011·PloS One·Radha DuttaguptaKeith W Jones
Jul 1, 2011·Genes and Immunity·K VandenbroeckA Aransay
Aug 13, 2011·Nature·UNKNOWN International Multiple Sclerosis Genetics ConsortiumAlastair Compston
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
Dec 1, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Haritz IrizarDavid Otaegui
Dec 30, 2011·Journal of Autoimmunity·Shashi AmurPadmaja Mummaneni
Mar 28, 2012·Nature Reviews. Neurology·Rhonda R Voskuhl, Stefan M Gold
Aug 21, 2012·Current Opinion in Immunology·Angela CeribelliEdward K L Chan
Sep 27, 2012·Biology of Sex Differences·Christopher P Morgan, Tracy L Bale
Feb 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yunzi ChenYan Chun Li
Apr 24, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Riley Bove, Tanuja Chitnis
Aug 8, 2013·International Journal of Molecular Sciences·Michael HeckerUwe Klaus Zettl
Oct 3, 2013·Multiple Sclerosis : Clinical and Laboratory Research·R RatzerF Sellebjerg
Oct 26, 2013·International Journal of Cardiology·Ana Maria QueirósVera Regitz-Zagrosek
Nov 1, 2013·Clinical & Developmental Immunology·Norma Y Hernández-PedroJulio Sotelo

❮ Previous
Next ❯

Citations

Jan 31, 2019·Brain : a Journal of Neurology·Achilles NtranosPatrizia Casaccia
Mar 12, 2020·Frontiers in Neurology·Zongpu ZhouYing Feng
Apr 21, 2017·Frontiers in Neurology·Elizabeth A MillsYang Mao-Draayer
May 31, 2018·Investigative Ophthalmology & Visual Science·Ander AnasagastiJavier Ruiz-Ederra
Sep 9, 2018·Scientific Reports·Camille A JuźwikAlyson E Fournier
Apr 3, 2019·Nucleic Acids Research·Tobias FehlmannAndreas Keller
Nov 23, 2018·International Journal of Molecular Sciences·Nicoletta NuzzielloMaria Liguori
Apr 22, 2021·Proceedings of the National Academy of Sciences of the United States of America·Galina Yurevna ZheleznyakovaMaja Jagodic

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
Assay

Software Mentioned

miRNA QC Tool
MultiExperiment Viewer
Excel
Expression Console
InCyte
ClueGO
Cytoscape
RStudio
miRDIP
Affymetrix

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Brain Research
Brooke H Miller, Claes Wahlestedt
Silence
Sanghamitra BandyopadhyayMichael Q Zhang
Autoimmune Diseases
Kemal Ugur TufekciKursad Genc
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Ettore Luzi, Maria Luisa Brandi
© 2021 Meta ULC. All rights reserved