Sneddon-Wilkinson disease induced by sorafenib in a patient with advanced hepatocellular carcinoma

Internal Medicine
Kazuto TajiriToshiro Sugiyama

Abstract

Sorafenib is the standard treatment for patients with advanced hepatocellular carcinoma (HCC), although it is known to cause a variety of dermatologic adverse events. Subcorneal pustular dermatosis (SCPD), also known as Sneddon-Wilkinson disease, is a rare skin eruption that accompanies various systemic disorders and may become chronically progressive. We herein describe the case of a patient who developed SCPD after sorafenib administration. The dermatologic reaction was improved by the cessation of sorafenib and worsened by its readministration. Clinicians treating HCC patients with sorafenib should be aware of the possibility of SCPD.

References

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Citations

Oct 2, 2015·Journal of Korean Medical Science·Hyung Seok KimSuk Woo Nam
Jun 29, 2016·American Journal of Clinical Dermatology·Paula Jean Watts, Amor Khachemoune

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