Sniffing out pharmacology: interactions of drugs with human olfaction

Trends in Pharmacological Sciences
Jörn LötschThomas Hummel

Abstract

Advances in the understanding of the sense of smell have increased awareness of the role of olfaction in human life. Odors are perceived via specific G protein-coupled receptors (GPCRs) with cAMP as the second messenger. Drugs that interact with this signaling cascade, such as opioids, cannabinoids and sildenafil, are known to reduce olfactory function. Drugs that are active in the central nervous system (CNS) may also hinder the complex processing of olfactory information to distinguish, via pattern recognition, thousands of odors from the signals of only ∼400 distinct olfactory receptors. Many other interactions with drug targets expressed at the olfactory bulb are also likely to occur. However, olfactory drug effects have rarely been explored in controlled studies. In the current activities of drug development and re-purposing, olfaction could become highly important because it can impact significantly upon the enjoyment of food. With an established molecular basis and using available tools, the assessment of olfaction in drug development and approval is advised.

References

Sep 1, 1992·Laryngo- rhino- otologie·R WeberT Bonzel
Apr 16, 1990·The Medical Journal of Australia·A F BleaselM Lane-Brown
May 1, 1985·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H ZumkleyH Losse
Jan 1, 1985·Annals of Internal Medicine·J L Levenson, K Kennedy
May 1, 1985·Annals of Internal Medicine·J L Berman
Oct 1, 1982·Journal of Clinical Pharmacology·E L KinneyR Zelis
Nov 1, 1994·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·R I Henkin
Dec 15, 1994·The Journal of Comparative Neurology·A MansourS J Watson
Nov 1, 1996·Biopharmaceutics & Drug Disposition·L IllumP N Shaw
Mar 25, 1999·Cell·B MalnicL B Buck
Jan 11, 2000·QJM : Monthly Journal of the Association of Physicians·C H HawkesS E Daniel
Feb 24, 2001·The Laryngoscope·A M Seiden, H J Duncan
May 5, 2001·Genome Research·G GlusmanD Lancet
Jul 26, 2002·Acta Anaesthesiologica Scandinavica·O DaleE D Kharasch
Jul 26, 2002·Current Opinion in Neurobiology·Ivanka Savic
Mar 20, 2003·Molecular Biology and Evolution·Yoav Gilad, Doron Lancet
Mar 28, 2003·Occupational and Environmental Medicine·E M H Haldorsen
Apr 12, 2003·Brain : a Journal of Neurology·Irmgard TegederJörn Lötsch
Nov 19, 2003·The Journal of Comparative Neurology·Wilma C G Van StaverenJan De Vente
Dec 17, 2003·Archives of Otolaryngology--head & Neck Surgery·Antje Welge-Luessen, Markus Wolfensberger
Mar 5, 2004·Cellular and Molecular Life Sciences : CMLS·I GaillardD Giorgi
May 12, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Antje Welge-LüssenGerd Kobal
Aug 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·David M LinJohn Ngai
Oct 27, 2004·Physiology & Behavior·M Knecht, T Hummel
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·William M Pardridge
Apr 29, 2005·Brain Research. Molecular Brain Research·Attila TóthPeter M Blumberg
Apr 29, 2005·Journal of Pharmaceutical Sciences·Candace L Graff, Gary M Pollack
May 11, 2005·Acta Oto-laryngologica·Thomas Hummel, Steven Nordin
Nov 5, 2005·Neuron·Barry W Ache, Janet M Young
Nov 16, 2005·British Journal of Anaesthesia·F SalvinelliF Agrò
Feb 10, 2006·The Laryngoscope·Thomas H Alexander, Terence M Davidson
Apr 7, 2006·Handbook of Experimental Pharmacology·R G Pertwee
Apr 7, 2006·Handbook of Experimental Pharmacology·K P LindseyS J Gatley
May 30, 2006·Cellular and Molecular Life Sciences : CMLS·I Menashe, D Lancet
Dec 13, 2006·The Journal of Urology·V GudziolT Hummel

❮ Previous
Next ❯

Citations

Aug 10, 2013·Brain Structure & Function·Jörn LötschAlfred Ultsch
Jul 24, 2013·BMC Ear, Nose, and Throat Disorders·Andreas Keller, Dolores Malaspina
Jul 15, 2015·Drug Discovery Today·Jörn LötschCarmen Walter
Sep 19, 2012·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Jörn LötschThomas Hummel
May 8, 2014·British Journal of Clinical Pharmacology·Carmen WalterJörn Lötsch
Jul 16, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Anna OleszkiewiczThomas Hummel
Feb 14, 2015·Journal of Neuroscience Methods·A SorokowskaT Hummel
Feb 11, 2015·European Journal of Clinical Pharmacology·Jörn LötschThomas Hummel
Nov 14, 2014·Chemical Senses·Jörn Lötsch, Thomas Hummel
Jul 23, 2013·PloS One·Dirk HeimannBruno G Oertel
Sep 4, 2017·European Journal of Clinical Pharmacology·Carmen WalterJörn Lötsch
Oct 30, 2018·Chemical Senses·Jörn LötschThomas Hummel
Apr 24, 2019·Ear, Nose, & Throat Journal·Katherine L WhitcroftThomas Hummel
Apr 25, 2020·International Journal of Molecular Sciences·Naina Bhatia-Dey, Thomas Heinbockel
Mar 11, 2020·Frontiers in Neuroscience·Victoria Van RegemorterCaroline Huart
Jun 27, 2021·The Journal of Membrane Biology·Mercedes Alfonso-Prieto
Aug 21, 2021·BMC Infectious Diseases·Paula JendrnyHolger Andreas Volk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.